Clinical Update on the Prevention and Management of Postoperative Crohn's Disease Recurrence

SP Bachour, BH Click - Current Gastroenterology Reports, 2024 - Springer
Abstract Purpose of Review Despite advances in therapeutics, a significant portion of
patients with Crohn's disease still require surgical management. In this article, we present …

[HTML][HTML] Timing of individualized surgical intervention in Crohn's disease

K Xia, RY Gao, XC Wu, L Yin… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with an
increasing incidence worldwide. Comprehensive therapy for CD focuses on symptom …

Long-term Outcomes of the Kono-S Anastomosis: A Multicenter Study

A Fichera, AM Mangrola, KS Olortegui… - Diseases of the Colon …, 2024 - journals.lww.com
BACKGROUND: Postoperative recurrence remains a significant problem in Crohn's disease,
and the mesentery is implicated in the pathophysiology. The Kono-S anastomosis was …

Clinical outcomes and perioperative morbidity and mortality following segmental resections of the colon for Crohn's colitis

AS Kappenberger, J Schardey, U Wirth, F Kühn… - International Journal of …, 2024 - Springer
Introduction Crohn's disease (CD) is a chronic inflammatory bowel disease of a multifactorial
pathogenesis. Recently numerous genetic variants linked to an aggressive phenotype were …

Crohn's Disease as a Possible Risk Factor for Failed Healing in Ileocolic Anastomoses

JT Schweer, PA Neumann, P Doebler… - Journal of Clinical …, 2023 - mdpi.com
Anastomotic leakage (AL) after colorectal resections is a serious complication in abdominal
surgery. Especially in patients with Crohn's disease (CD), devastating courses are observed …

Postoperative Crohn's Disease Recurrence Risk and Optimal Biologic Timing After Temporary Diversion Following Ileocolic Resection

A Joseph, SP Bachour, R Shah… - Inflammatory Bowel …, 2024 - academic.oup.com
Abstract Background Postoperative recurrence of Crohn's disease (CD) is common. While
most patients undergo resection with undiverted anastomosis (UA), some individuals also …

[HTML][HTML] Oral Budesonide and low serum albumin levels at surgery are associated with a higher risk of postoperative intra-abdominal septic complications after primary …

G Dajti, S Cardelli, G Calini, F Rizzello… - Digestive and Liver …, 2024 - Elsevier
Abstract Background and Aims The terminal ileum is the most frequent site of Crohn's
Disease (CD) that necessitates surgery. Of the postoperative complications (POCs) …

Anastomotic configuration and temporary diverting ileostomy do not increase risk for anastomotic stricture in postoperative Crohn's disease

SP Bachour, MZ Khan, RS Shah… - Official journal of the …, 2022 - journals.lww.com
Background: Surgical management of Crohn's disease (CD) is common. Postoperative
complications include anastomotic stricturing (AS). The natural history and risk factors for AS …

Targeting the mesentery with surgery in ileocolic Crohn's disease: where do we stand?

B Click, SD Holubar - The Lancet Gastroenterology & Hepatology, 2024 - thelancet.com
Eline M van der Does de Willebois and colleagues present the short-term results of the
SPICY randomised controlled trial (RCT) of extended mesenteric excision versus a …

Perioperative low-dose prednisolone treatment has beneficial effects on postoperative recovery and anastomotic healing in a murine colitis model

MC Weber, J Bauer, A Buck, Z Clees… - Journal of Crohn's …, 2023 - academic.oup.com
Abstract Background and Aims High-dose glucocorticoid treatment has been identified as a
risk factor for anastomotic leakage in patients with inflammatory bowel disease [IBD] …