Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider
Objectives To systematically review the literature for assay methods that aim to evaluate type
I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods Three …
I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods Three …
[PDF][PDF] Type I interferon signature in Sjögren's syndrome: Pathophysiological and clinical implications
N Marketos, I Cinoku, A Rapti… - Clin Exp …, 2019 - clinexprheumatol.org
Type I interferons (IFN) have long been recognised as mediators of innate immune defense
mechanisms against viral threats. Robust evidence over the last 15 years revealed their …
mechanisms against viral threats. Robust evidence over the last 15 years revealed their …
Interfering with interferons: targeting the JAK-STAT pathway in complications of systemic juvenile idiopathic arthritis (SJIA)
EL Verweyen, GS Schulert - Rheumatology, 2022 - academic.oup.com
Systemic JIA (SJIA) is distinguished from other forms of JIA by the prevalence of the severe,
life-threatening complications macrophage activation syndrome (SJIA-MAS) and lung …
life-threatening complications macrophage activation syndrome (SJIA-MAS) and lung …
The role of interferons in the pathogenesis of Sjögren's syndrome and future therapeutic perspectives
N Del Papa, A Minniti, M Lorini, V Carbonelli… - Biomolecules, 2021 - mdpi.com
There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the
pathogenesis of different systemic autoimmune diseases, including primary Sjögren's …
pathogenesis of different systemic autoimmune diseases, including primary Sjögren's …
Type 1 Interferon‐Stimulated Gene Expression and Disease Activity in Pediatric Rheumatic Diseases: No Composite Scores Needed?
C Weiden, M Saers, T Schwarz, T Hinze… - ACR Open …, 2023 - Wiley Online Library
Objective Rheumatic diseases are characterized by different patterns of immune
overactivation. This study investigated the correlation of whole blood type 1 interferon (IFN) …
overactivation. This study investigated the correlation of whole blood type 1 interferon (IFN) …
2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice
J Rodríguez-Carrio, A Burska, PG Conaghan… - Annals of the …, 2023 - ard.bmj.com
Background Type I interferons (IFN-Is) play a role in a broad range of rheumatic and
musculoskeletal diseases (RMDs), and compelling evidence suggests that their …
musculoskeletal diseases (RMDs), and compelling evidence suggests that their …
Differential RNA editing landscapes in host cell versus the SARS-CoV-2 genome
M Kurkowiak, S Fletcher, A Daniels, P Mozolewski… - Iscience, 2023 - cell.com
The SARS-CoV-2 pandemic was defined by the emergence of new variants formed through
virus mutation originating from random errors not corrected by viral proofreading and/or the …
virus mutation originating from random errors not corrected by viral proofreading and/or the …
A clinical score to guide in decision making for monogenic type I IFNopathies
HE Sönmez, C Karaaslan, AA de Jesus, ED Batu… - Pediatric …, 2020 - nature.com
Objective To develop a set of clinical criteria that identifies patients with a potential
autoinflammatory IFNopathy. Methods Based on a literature review, a set of clinical criteria …
autoinflammatory IFNopathy. Methods Based on a literature review, a set of clinical criteria …
CD169 expression on monocytes as a marker for assessing type I interferon status in pediatric inflammatory diseases
N Sakumura, T Yokoyama, M Usami, Y Hosono… - Clinical …, 2023 - Elsevier
Background Evaluation of type I interferons (IFNs) in inflammatory or autoimmune diseases
is challenging because of their rapid clearance in peripheral blood. The IFN gene …
is challenging because of their rapid clearance in peripheral blood. The IFN gene …
Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
L Lamot, I Niemietz, KL Brown - BMC research notes, 2019 - Springer
Abstract Objective Type I interferons (IFN) have important roles in many immune-mediated
inflammatory diseases (IMIDs) and are a relatively new therapeutic target. Direct detection of …
inflammatory diseases (IMIDs) and are a relatively new therapeutic target. Direct detection of …