Objectives To systematically review the literature for assay methods that aim to evaluate type
I interferon (IFN-I) pathway activation and to harmonise-related terminology. Methods Three …

Type I interferons (IFN) have long been recognised as mediators of innate immune defense
mechanisms against viral threats. Robust evidence over the last 15 years revealed their …

Systemic JIA (SJIA) is distinguished from other forms of JIA by the prevalence of the severe,
life-threatening complications macrophage activation syndrome (SJIA-MAS) and lung …

There is a great deal of evidence pointing to interferons (IFNs) as being key cytokines in the
pathogenesis of different systemic autoimmune diseases, including primary Sjögren's …

Objective Rheumatic diseases are characterized by different patterns of immune
overactivation. This study investigated the correlation of whole blood type 1 interferon (IFN) …

Background Type I interferons (IFN-Is) play a role in a broad range of rheumatic and
musculoskeletal diseases (RMDs), and compelling evidence suggests that their …

The SARS-CoV-2 pandemic was defined by the emergence of new variants formed through
virus mutation originating from random errors not corrected by viral proofreading and/or the …

Objective To develop a set of clinical criteria that identifies patients with a potential
autoinflammatory IFNopathy. Methods Based on a literature review, a set of clinical criteria …

Background Evaluation of type I interferons (IFNs) in inflammatory or autoimmune diseases
is challenging because of their rapid clearance in peripheral blood. The IFN gene …

Abstract Objective Type I interferons (IFN) have important roles in many immune-mediated
inflammatory diseases (IMIDs) and are a relatively new therapeutic target. Direct detection of …