The role of lipids in cancer progression and metastasis
M Martin-Perez, U Urdiroz-Urricelqui, C Bigas… - Cell metabolism, 2022 - cell.com
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …
as a signaling molecule, and being a structural component of membranes); however, an …
Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
Fatty acyl recognition and transfer by an integral membrane S-acyltransferase
INTRODUCTION Hundreds of cellular proteins are modified by posttranslational S-acylation
of cysteines, commonly known as protein palmitoylation. Unlike other lipid attachments …
of cysteines, commonly known as protein palmitoylation. Unlike other lipid attachments …
[HTML][HTML] DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and …
X Le, J Mu, W Peng, J Tang, Q Xiang, S Tian, Y Feng… - Theranostics, 2020 - ncbi.nlm.nih.gov
Cancer progression is an intricate biological process profiled by not only unscheduled
proliferation, but also altered metabolism mechanisms. In this article, we introduced a novel …
proliferation, but also altered metabolism mechanisms. In this article, we introduced a novel …
[HTML][HTML] Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking
Palmitoylation, a key regulatory mechanism controlling protein targeting, is catalyzed by
DHHC-family palmitoyl acyltransferases (PATs). Impaired PAT activity is linked to …
DHHC-family palmitoyl acyltransferases (PATs). Impaired PAT activity is linked to …
The molecular era of protein S-acylation: spotlight on structure, mechanisms, and dynamics
ME Zaballa, FG van der Goot - Critical Reviews in Biochemistry …, 2018 - Taylor & Francis
S-Acylation (commonly referred to as S-palmitoylation) is a post-translational modification
consisting in the covalent attachment of an acyl chain to a cysteine residue of the target …
consisting in the covalent attachment of an acyl chain to a cysteine residue of the target …
Emerging roles of DHHC-mediated protein S-palmitoylation in physiological and pathophysiological context
I De, S Sadhukhan - European journal of cell biology, 2018 - Elsevier
Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …
Human DHHC proteins: a spotlight on the hidden player of palmitoylation
J Korycka, A Łach, E Heger, DM Bogusławska… - European journal of cell …, 2012 - Elsevier
Palmitoylation is one of the most common posttranslational lipid modifications of proteins
and we now know quite a lot about it. However, the state of knowledge about the enzymes …
and we now know quite a lot about it. However, the state of knowledge about the enzymes …
Protein S-palmitoylation and cancer
M Yeste-Velasco, ME Linder, YJ Lu - … et Biophysica Acta (BBA)-Reviews on …, 2015 - Elsevier
Protein S-palmitoylation is a reversible posttranslational modification of proteins with fatty
acids, an enzymatic process driven by a recently discovered family of protein …
acids, an enzymatic process driven by a recently discovered family of protein …