[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - … and Targeted Therapy, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

G Wei, K Lu, M Umar, Z Zhu, WW Lu, JR Speakman… - Bone Research, 2023 - nature.com
Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …

[HTML][HTML] Osteoarthritis as an umbrella term for different subsets of humans undergoing joint degeneration: The need to address the differences to develop effective …

DA Hart - International Journal of Molecular Sciences, 2022 - mdpi.com
Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of
individuals affected is expected to continue to rise. Currently, conservative treatments after …

[HTML][HTML] Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways

T Cui, Y Lan, Y Lu, F Yu, S Lin, Y Fu, J Qiu… - Aging (Albany NY …, 2023 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a chronic and complicated degenerative disease for which there is
currently no effective treatment. Isoorientin (ISO) is a natural plant extract that has …

Therapeutic potentials of ononin with mechanistic insights: A comprehensive review

MS Bhuia, MA Aktar, R Chowdhury, J Ferdous… - Food Bioscience, 2023 - Elsevier
Ononin is a naturally occurring isoflavone glycoside generally found in various plants like
soybeans, legumes, Chinese licorice, Mongolian milkvetch, kudzu, broccoli, and lupine. The …

Phototherapy techniques for the management of musculoskeletal disorders: strategies and recent advances

Z Zhang, R Wang, H Xue, S Knoedler, Y Geng… - Biomaterials …, 2023 - spj.science.org
Musculoskeletal disorders (MSDs), which include a range of pathologies affecting bones,
cartilage, muscles, tendons, and ligaments, account for a significant portion of the global …

Novel strategies for the treatment of osteoarthritis based on biomaterials and critical molecular signaling

X Huang, Z Wang, H Wang, D Chen, L Tong - Journal of Materials Science …, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative disease involving entire joint. It is often initiated from
the low-grade inflammation in synovial tissue and then affects articular cartilage and …

Hypoxia and Matrix Metalloproteinase 13‐Responsive Hydrogel Microspheres Alleviate Osteoarthritis Progression In Vivo

T Zhou, H Xiong, SY Yao, S Wang, S Li, J Chang… - Small, 2023 - Wiley Online Library
The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …

Battling colorectal cancer via s-triazine-based MMP-10/13 inhibitors armed with electrophilic warheads for concomitant ferroptosis induction; the first-in-class dual …

CA Morcos, SN Khattab, NS Haiba, RW Bassily… - Bioorganic …, 2023 - Elsevier
There is an increasing interest in halting CRC by combining ferroptosis with other forms of
tumor cell death. However, ferroptosis induction is seldom studied in tandem with inhibiting …

Undenatured type II collagen and its role in improving osteoarthritis

R Xu, J Wu, L Zheng, M Zhao - Ageing Research Reviews, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease, affecting 32.5 million US adults or 242
million people worldwide. There is no cure for OA. Many animal and clinical trials showed …