[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - … and Targeted Therapy, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …
[HTML][HTML] Osteoarthritis as an umbrella term for different subsets of humans undergoing joint degeneration: The need to address the differences to develop effective …
DA Hart - International Journal of Molecular Sciences, 2022 - mdpi.com
Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of
individuals affected is expected to continue to rise. Currently, conservative treatments after …
individuals affected is expected to continue to rise. Currently, conservative treatments after …
[HTML][HTML] Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways
T Cui, Y Lan, Y Lu, F Yu, S Lin, Y Fu, J Qiu… - Aging (Albany NY …, 2023 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a chronic and complicated degenerative disease for which there is
currently no effective treatment. Isoorientin (ISO) is a natural plant extract that has …
currently no effective treatment. Isoorientin (ISO) is a natural plant extract that has …
Therapeutic potentials of ononin with mechanistic insights: A comprehensive review
Ononin is a naturally occurring isoflavone glycoside generally found in various plants like
soybeans, legumes, Chinese licorice, Mongolian milkvetch, kudzu, broccoli, and lupine. The …
soybeans, legumes, Chinese licorice, Mongolian milkvetch, kudzu, broccoli, and lupine. The …
Phototherapy techniques for the management of musculoskeletal disorders: strategies and recent advances
Z Zhang, R Wang, H Xue, S Knoedler, Y Geng… - Biomaterials …, 2023 - spj.science.org
Musculoskeletal disorders (MSDs), which include a range of pathologies affecting bones,
cartilage, muscles, tendons, and ligaments, account for a significant portion of the global …
cartilage, muscles, tendons, and ligaments, account for a significant portion of the global …
Novel strategies for the treatment of osteoarthritis based on biomaterials and critical molecular signaling
Osteoarthritis (OA) is a degenerative disease involving entire joint. It is often initiated from
the low-grade inflammation in synovial tissue and then affects articular cartilage and …
the low-grade inflammation in synovial tissue and then affects articular cartilage and …
Hypoxia and Matrix Metalloproteinase 13‐Responsive Hydrogel Microspheres Alleviate Osteoarthritis Progression In Vivo
T Zhou, H Xiong, SY Yao, S Wang, S Li, J Chang… - Small, 2023 - Wiley Online Library
The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …
Battling colorectal cancer via s-triazine-based MMP-10/13 inhibitors armed with electrophilic warheads for concomitant ferroptosis induction; the first-in-class dual …
CA Morcos, SN Khattab, NS Haiba, RW Bassily… - Bioorganic …, 2023 - Elsevier
There is an increasing interest in halting CRC by combining ferroptosis with other forms of
tumor cell death. However, ferroptosis induction is seldom studied in tandem with inhibiting …
tumor cell death. However, ferroptosis induction is seldom studied in tandem with inhibiting …
Undenatured type II collagen and its role in improving osteoarthritis
R Xu, J Wu, L Zheng, M Zhao - Ageing Research Reviews, 2023 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease, affecting 32.5 million US adults or 242
million people worldwide. There is no cure for OA. Many animal and clinical trials showed …
million people worldwide. There is no cure for OA. Many animal and clinical trials showed …