Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …

Budding is a process during which individual or small clusters of up to five tumour cells
detach from the main tumour mass and invade into the surrounding stroma. In colorectal …

Lung cancer is one of the most aggressive tumours with very low life expectancy. Altered
microRNA expression is found in human tumours because it is involved in tumour growth …

Abstract β-catenin is a major transcriptional activator of the canonical Wnt/β-catenin
signaling pathway. It is important for a series of biological processes including tissue …

APC mutations activate aberrant β-catenin signaling to drive initiation of colorectal cancer;
however, colorectal cancer progression requires additional molecular mechanisms. PPAR …

Rationale: β-catenin is a component for cell adhesion and a transcriptional coactivator in
epithelial-mesenchymal transition (EMT). Previously we found that catalytically active PLK1 …

Polystyrene nano-and micro-sized plastic particles (NMP) are one of the common plastic
materials produced that dramatically pollute the environment, water, and oceanic habitats …

NEK9 is a key player in the NEK9–EG5 axis for microtubule polymerization, chromosome
alignment, and mitosis. In present study, we investigated the altered expression of the NEK9 …

The pathogenesis of pancreatic ductal adenocarcinoma (PDAC) remains poorly understood.
S100 calcium-binding protein A6 (S100A6) has been associated with PDAC; however, the …

Abstract Programmed cell death‐1 (PD‐1) and its ligand (PD‐L1) are significant mediators
of immune suppression in the tumor microenvironment. We focused on the immunological …