Inhibition of Notch signalling with a gamma-secretase inhibitor (GSI) induces mammalian
hair cell regeneration and partial hearing restoration. In this proof-of-concept Phase I/IIa …

Background Mesenchymal stem cell (MSC) transplantation is a promising therapeutic
approach for noise-induced hearing loss (NIHL). As the indispensable role of apoptosis in …

Introduction: Hearing loss has a high prevalence, with aging, noise exposure, ototoxic drug
therapies, and genetic mutations being some of the leading causes of hearing loss. Health …

Hearing loss constitutes a major global health concern impacting approximately 1.5 billion
people worldwide. Its incidence is undergoing a substantial surge with some projecting that …

Abstract The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in
the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been …

It is estimated that hearing loss currently affects more than 1.5 billion people, or
approximately 20% of the global population; however, presently, there are no Food and …

Hearing loss is a worldwide epidemic, with approximately 1.5 billion people currently
struggling with hearing-related conditions. Currently, the most wildly used and effective …

Background The genes involved in inner ear development and maintenance of the adult
organ have yet to be fully characterized. Previous genetic analysis has emphasized the …

A series of articles discussing advanced diagnostics that can be used to assess noise injury
and associated noise-induced hearing disorders (NIHD) was developed under the umbrella …

RESUMO O presente relatório foi realizado no âmbito da unidade curricular Estágio, a qual
marca o fim do meu percurso no Mestrado Integrado em Ciências Farmacêuticas. O meu …