Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

Introduction: Phytochemicals have garnered much attention because they are useful in
managing several human diseases. Yohimbine is one such phytochemical with significant …

A class of piperazine hybridized coumarin indolylcyanoenones was exploited as new
structural antibacterial frameworks to combat intractable bacterial resistance. Bioactive …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Significant progress has been made in asymmetric synthesis through the use of transition
metal catalysts combined with Lewis bases. However, the use of a dual catalytic system …

Developing diversity-oriented synthetic approaches for medium-sized rings is of great
interest, and the divergent synthesis of medium-sized rings with different ring sizes poses a …

A series of multifunctional dihydroquinolinone frameworks have been synthesized via
synergistic catalysis combining photolysis and Lewis base catalysis utilizing in situ …

Allosteric modulation is a direct and effective method for regulating the function of biological
macromolecules, which play vital roles in various cellular activities. Unlike orthosteric …

Idiopathic pulmonary fibrosis is a progressive, irreversible lung disease that leads to
respiratory failure and death. Vincamine is an indole alkaloid obtained from the leaves of …

The Red Sea marine fungus Penicillium chrysogenum (Family: Ascomycota) comprises a
panel of chemically diverse natural metabolites. A meleagrin alkaloid was isolated from …