The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …

While type I interferons (IFNs) are universally acknowledged for their antiviral and
immunostimulatory functions, there is increasing appreciation of the detrimental effects of …

The microbiota is known to modulate the host response to influenza infection through as-yet-
unclear mechanisms. We hypothesized that components of the microbiota exert effects …

Influenza symptoms vary from mild disease to death; however, determinants of severity are
unclear. Type I interferons (IFNαβ) are recognized as key antiviral cytokines. Here we show …

Mitohormesis defines the increase in fitness mediated by adaptive responses to mild
mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial …

Influenza virus-infected cells vary widely in their expression of viral genes and only
occasionally activate innate immunity. Here, we develop a new method to assess how the …

The type I interferon (IFN) response represents one of the first lines of defense against
influenza virus infections. In this study, we assessed the protective potential of exogenous …

Despite efforts made to develop efficient preventive strategies, infections with influenza A
viruses (IAV) continue to cause serious clinical and economic problems. Current licensed …

Influenza viruses are globally important human respiratory pathogens. These viruses cause
seasonal epidemics and occasional worldwide pandemics, both of which can vary …

Influenza viruses (IVs) are a continual threat to global health. The high mutation rate of the IV
genome makes this virus incredibly successful, genetic drift allows for annual epidemics …