The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is
a transmembrane glycoprotein encoded by a gene located on 20p11. 21 and composed of …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

The intricate interplay between gut microbes and the onset of experimental autoimmune
encephalomyelitis (EAE) remains poorly understood. Here, we uncover remarkable …

Abstract Ethnopharmacological relevance Traditional Chinese medicine has gained
significant attention in recent years owing to its multi-component, multi-target, and multi …

Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

The central nervous system (CNS) influences the immune system generally by regulating
the systemic concentration of humoral substances (eg, cortisol and epinephrine), whereas …

Interferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic
rejuvenated the interest in interferon biology in health and disease, opening translational …

Multiple sclerosis is an important neurological disease affecting millions of young patients
globally. It is encouraging that more than ten disease-modifying drugs became available for …