Environmental exposures interplay with human host factors to promote the development and
progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a …

Type-2-cell-mediated immunity, rich in eosinophils, basophils, mast cells, CD4+ T helper 2
(Th2) cells, and type 2 innate lymphoid cells (ILC2s), protects the host from helminth …

Asthma is a T lymphocyte–controlled disease of the airway wall caused by inflammation,
overproduction of mucus and airway wall remodeling leading to bronchial hyperreactivity …

Air pollution and climate change are potential drivers for the increasing burden of allergic
diseases. The molecular mechanisms by which air pollutants and climate parameters may …

The discovery of IgE represented a major breakthrough in allergy and asthma research,
whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti …

House dust mite (HDM) is one of the most common allergens worldwide. In this study, we
have addressed the involvement of IL-1 in the interaction between HDM and the innate …

Allergic sensitization to inhaled antigens is common but poorly understood. Although lung
epithelial cells were initially merely regarded as a passive barrier impeding allergen …

Originally shown to promote the growth and activation of B cells, thymic stromal
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …

The exposure of the airway epithelium to external stimuli such as allergens, microbes, and
air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal …

Recent genetic, structural and functional studies have identified the airway and lung
epithelium as a key orchestrator of the immune response. Further, there is now strong …