Non-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis and inflammation
and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the …

Approximately 4 million persons in the United States and probably more than 100 million
persons worldwide are infected with hepatitis C virus. The virus has the unique ability to …

Objective Immune responses are important in dictating non-alcoholic steatohepatitis (NASH)
outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin …

Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis,
suggesting that immune responses contribute to nonalcoholic fatty liver disease (NAFLD) …

Because of its location and function, the liver is continuously exposed to a large antigenic
load that includes pathogens, toxins, tumor cells and harmless dietary antigens. The range …

The immune response against hepatitis C virus (HCV) is rarely effective at clearing the virus,
resulting in∼ 170 million chronic HCV infections worldwide. Here we report that ligation of …

CD4+ CD25+ Foxp3+ Tregs suppress autoimmune responses. In addition, they limit T cell
responses during chronic infection, thereby minimizing T cell–dependent immunopathology …

Acute infection with hepatitis C virus (HCV) is usually asymptomatic and therefore rarely
recognized. It is thus not surprising that as a clinical entity, acute hepatitis C has been …

It is believed that the hepatitis C virus (HCV)-specific CD8+ cytotoxic T lymphocytes (CTLs)
play a role in the development of liver cell injury and in the clearance of the virus. To …

Hepatitis C virus (HCV) infection is a prevalent infection in most developed countries
affecting 1.5–2% of the general population [1]. The natural history of this infection has been …