Normal individuals have mature T lymphocytes that are capable of reacting to self‐antigens
and can be activated by cross‐reacting environmental antigens. The mechanism that …

Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT),
natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have …

Hepatitis C virus (HCV) is remarkably efficient in establishing persistent infection, possibly
mediated by an impaired immune response to HCV infection. There is compelling evidence …

Persistent viral infection, such as HCV infection, is the result of the inability of the host
immune system to mount a successful antiviral response, as well as the escape strategies …

Hepatitis C virus (HCV) is a small, enveloped RNA virus and a major cause of chronic liver
disease. Resolution of primary HCV infections depends upon the vigorous responses of …

Changes in Vα24+ Vβ11+ NKT cell number and function are associated with human
autoimmune diseases and cancer. Restoration of this corresponding NKT cell population in …

Cell-free virus is a well-recognized and efficient mechanism for the spread of hepatitis B
virus (HBV) infection in the liver. Cell-to-cell transmission (CCT) can be a more efficient …

The healthy liver of adult humans has little or no lymphocyte component and the histological
finding of intrahepatic lymphocytes (IHL) is evidence of liver pathology. In a liver injured by …

We had previously reported the cloning of the complete genome of an isolate of hepatitis C
virus (HCV), HCV-S1, of genotype 1b. We have constructed a full-length complementary …

Immunity to allogeneic MHC Ags is weak in rodent livers, raising questions as to the
mechanisms that might control responses in this organ. Infection with an adenovirus vector …