T cell costimulation by the hepatitis C virus envelope protein E2 binding to CD81 is mediated by Lck
Binding of the hepatitis C virus (HCV) envelope protein E2 to CD81 provides a costimulatory
signal for human T cells. This phenomenon may play a role in liver damage and …
signal for human T cells. This phenomenon may play a role in liver damage and …
Perspectives for a vaccine against hepatitis C virus
S Abrignani, M Houghton, HH Hsu - Journal of hepatology, 1999 - Elsevier
There is no vaccine for HCV and the only available treatment, IFNα alone or in combination
with ribavirin, has proven efficacious in less than 50% of patients. Given that approximately …
with ribavirin, has proven efficacious in less than 50% of patients. Given that approximately …
Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
F Lolli, H Martini, A Citro, D Franceschini… - Journal of …, 2013 - Springer
Background Here, we evaluated the hypothesis that CD8+ T cell responses to caspase-
cleaved antigens derived from effector T cells undergoing apoptosis, may contribute to …
cleaved antigens derived from effector T cells undergoing apoptosis, may contribute to …
CD8+ T-cell interaction with HCV replicon cells: evidence for both cytokine-and cell-mediated antiviral activity
The interaction between the host immune response and infected hepatocytes plays a central
role in the pathogenesis of hepatitis C virus (HCV). The lack of a suitable animal or in vitro …
role in the pathogenesis of hepatitis C virus (HCV). The lack of a suitable animal or in vitro …
CD8+ T Cells Specific to Apoptosis-Associated Antigens Predict the Response to Tumor Necrosis Factor Inhibitor Therapy in Rheumatoid Arthritis
A Citro, R Scrivo, H Martini, C Martire, P De Marzio… - PloS one, 2015 - journals.plos.org
CD8+ T cells specific to caspase-cleaved antigens derived from apoptotic T cells (apoptotic
epitopes) represent a principal player in chronic immune activation, which is known to …
epitopes) represent a principal player in chronic immune activation, which is known to …
[HTML][HTML] Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL …
K Iken, L Huang, H Bekele, EV Schmidt, MJ Koziel - Virology, 2006 - Elsevier
A central unresolved issue in hepatitis C virus (HCV) infection is how the virus establishes
chronic infection. Recent studies suggest that the liver microenvironment leads to apoptosis …
chronic infection. Recent studies suggest that the liver microenvironment leads to apoptosis …
Biology and significance of T‐cell apoptosis in the liver
S Park, D Murray, B John… - Immunology and cell …, 2002 - Wiley Online Library
The liver has emerged as an organ with distinct immunological properties. In this review, we
summarize evidence that shows that the liver can remove apoptotic, or non‐apoptotic but …
summarize evidence that shows that the liver can remove apoptotic, or non‐apoptotic but …
Predominance of type 1 (Th1) cytokine production in the liver of patients with HCV-associated mixed cryoglobulinemia vasculitis
D Saadoun, O Boyer, H Trébeden-Nègre, N Limal… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Patients with hepatitis C virus (HCV) mixed cryoglobulinemia (MC)
vasculitis have a higher mortality rate and more frequent incidence of cirrhosis than their …
vasculitis have a higher mortality rate and more frequent incidence of cirrhosis than their …
[HTML][HTML] NKT cells and HIV infection
D Unutmaz - Microbes and infection, 2003 - Elsevier
Natural killer T (NKT) cells are a subset of lymphocytes that express a semi-invariant T cell
receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I …
receptor (TCR) that recognizes glycolipids presented by the non-polymorphic MHC class I …
Expression of chemokine receptors on intrahepatic and peripheral lymphocytes in chronic hepatitis C infection: its relationship to liver inflammation
J Wang, TH Holmes, R Cheung… - Journal of Infectious …, 2004 - academic.oup.com
Background. Intrahepatic lymphocytes are believed to be directly involved in the
immunopathogenesis of chronic liver diseases. Little is known about the trafficking of …
immunopathogenesis of chronic liver diseases. Little is known about the trafficking of …