Parkinson's disease (PD) is the second most common progressive age-related
neurodegenerative disorder. Paramount evidence shed light on the role of PI3K/AKT …

Ferroptosis is an iron-dependent form of programmed cell death driven by excessive
oxidation of polyunsaturated phospholipids on cellular membranes. Accumulating evidence …

Oxidative stress and mitochondrial dysfunction have been believed to play an important role
in the pathogenesis of aging and neurodegenerative diseases, including Parkinson's …

Cognitive impairment in patients with Parkinson's disease (PD) is one of the commonest and
most disabling non-motor manifestations during the course of the disease. The clinical …

Parkinson's disease (PD) is a neurodegenerative disease characterized by motor deficits
and marked neuroinflammation in various brain regions. The pathophysiology of PD is …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

Neurodegenerative diseases (NDs) are becoming a serious public health concern as the
world's population continues to age, demanding the discovery of more effective therapies …

Background Diabetes is associated with incidence and prevalence of Parkinson's disease
(PD). Furthermore, glycated hemoglobin (HbA1c) levels have been linked with motor …

Cognitive impairment is the most frequent non-motor symptom in Parkinson's disease and is
associated with deficits in a number of cognitive functions including working memory …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …