Cognitive impairment in Parkinson's disease: an updated overview focusing on emerging pharmaceutical treatment approaches
Y Degirmenci, E Angelopoulou, VE Georgakopoulou… - Medicina, 2023 - mdpi.com
Cognitive impairment in patients with Parkinson's disease (PD) is one of the commonest and
most disabling non-motor manifestations during the course of the disease. The clinical …
most disabling non-motor manifestations during the course of the disease. The clinical …
Clinical features and outcomes of hospitalised patients with COVID-19 and Parkinsonian disorders: A multicentre UK-based study
Background Parkinson's disease has been identified as a risk factor for severe Coronavirus
disease 2019 (COVID-19) outcomes. However, whether the significant high risk of death …
disease 2019 (COVID-19) outcomes. However, whether the significant high risk of death …
Chaudhuri's Dashboard of Vitals in Parkinson's syndrome: an unmet need underpinned by real life clinical tests
We have recently published the notion of the “vitals” of Parkinson's, a conglomeration of
signs and symptoms, largely nonmotor, that must not be missed and yet often not considered …
signs and symptoms, largely nonmotor, that must not be missed and yet often not considered …
Machine learning-based prediction of longitudinal cognitive decline in early Parkinson's disease using multimodal features
Abstract Patients with Parkinson's Disease (PD) often suffer from cognitive decline. Accurate
prediction of cognitive decline is essential for early treatment of at-risk patients. The aim of …
prediction of cognitive decline is essential for early treatment of at-risk patients. The aim of …
GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics
V Ugale, R Deshmukh, D Lokwani… - Molecular Diversity, 2023 - Springer
N-methyl-D-aspartate receptors (NMDARs) play essential roles in vital aspects of brain
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …
Modified SqueezeNet architecture for Parkinson's disease detection based on keypress data
LS Bernardo, R Damaševičius, SH Ling… - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is the most common form of Parkinsonism, which is a group of
neurological disorders with PD-like motor impairments. The disease affects over 6 million …
neurological disorders with PD-like motor impairments. The disease affects over 6 million …
Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective
Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling
neurodegenerative diseases globally. Both are proteinopathic conditions and while …
neurodegenerative diseases globally. Both are proteinopathic conditions and while …
Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive …
disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive …
The long-term trend of Parkinson's disease incidence and mortality in China and a Bayesian projection from 2020 to 2030
F Chen, S Chen, A Si, Y Luo, W Hu… - Frontiers in aging …, 2022 - frontiersin.org
Background: Parkinson's disease is a disabling degenerative disease of the central nervous
system that occurs mainly in elderly people. The changes in the incidence and mortality of …
system that occurs mainly in elderly people. The changes in the incidence and mortality of …
[HTML][HTML] No laughing white matter: Reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment
RA Crockett, KB Wilkins, S Aditham… - Neurobiology of …, 2023 - Elsevier
Background Approximately one third of recently diagnosed Parkinson's disease (PD)
patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates …
patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates …