Cognitive impairment in Parkinson's disease: an updated overview focusing on emerging pharmaceutical treatment approaches

Y Degirmenci, E Angelopoulou, VE Georgakopoulou… - Medicina, 2023 - mdpi.com
Cognitive impairment in patients with Parkinson's disease (PD) is one of the commonest and
most disabling non-motor manifestations during the course of the disease. The clinical …

Clinical features and outcomes of hospitalised patients with COVID-19 and Parkinsonian disorders: A multicentre UK-based study

L Sorrell, V Leta, A Barnett, K Stevens, A King, J Inches… - PloS one, 2023 - journals.plos.org
Background Parkinson's disease has been identified as a risk factor for severe Coronavirus
disease 2019 (COVID-19) outcomes. However, whether the significant high risk of death …

Chaudhuri's Dashboard of Vitals in Parkinson's syndrome: an unmet need underpinned by real life clinical tests

MA Qamar, S Rota, L Batzu, I Subramanian… - Frontiers in …, 2023 - frontiersin.org
We have recently published the notion of the “vitals” of Parkinson's, a conglomeration of
signs and symptoms, largely nonmotor, that must not be missed and yet often not considered …

Machine learning-based prediction of longitudinal cognitive decline in early Parkinson's disease using multimodal features

H Almgren, M Camacho, A Hanganu, M Kibreab… - Scientific Reports, 2023 - nature.com
Abstract Patients with Parkinson's Disease (PD) often suffer from cognitive decline. Accurate
prediction of cognitive decline is essential for early treatment of at-risk patients. The aim of …

GluN2B subunit selective N-methyl-D-aspartate receptor ligands: Democratizing recent progress to assist the development of novel neurotherapeutics

V Ugale, R Deshmukh, D Lokwani… - Molecular Diversity, 2023 - Springer
N-methyl-D-aspartate receptors (NMDARs) play essential roles in vital aspects of brain
functions. NMDARs mediate clinical features of neurological diseases and thus, represent a …

Modified SqueezeNet architecture for Parkinson's disease detection based on keypress data

LS Bernardo, R Damaševičius, SH Ling… - Biomedicines, 2022 - mdpi.com
Parkinson's disease (PD) is the most common form of Parkinsonism, which is a group of
neurological disorders with PD-like motor impairments. The disease affects over 6 million …

Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective

R Banerjee, A Rai, SM Iyer, S Narwal… - Animal models and …, 2022 - Wiley Online Library
Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling
neurodegenerative diseases globally. Both are proteinopathic conditions and while …

Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes

N Okkels, MJ Grothe, JP Taylor, SG Hasselbalch… - Brain, 2024 - academic.oup.com
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive …

The long-term trend of Parkinson's disease incidence and mortality in China and a Bayesian projection from 2020 to 2030

F Chen, S Chen, A Si, Y Luo, W Hu… - Frontiers in aging …, 2022 - frontiersin.org
Background: Parkinson's disease is a disabling degenerative disease of the central nervous
system that occurs mainly in elderly people. The changes in the incidence and mortality of …

[HTML][HTML] No laughing white matter: Reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment

RA Crockett, KB Wilkins, S Aditham… - Neurobiology of …, 2023 - Elsevier
Background Approximately one third of recently diagnosed Parkinson's disease (PD)
patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates …