Background Despite the close relationship between sleep–wake cycles and depression
symptoms, the relationship between sleep midpoint and depression symptoms in adults …

The ubiquitous daily rhythms in mammalian physiology are guided by progression of the
circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro …

Background Perinatal depression is a global mental health problem. Studies have
suggested that perinatal depression is related to poor sleep quality during pregnancy …

The suprachiasmatic nucleus (SCN) is the central clock for circadian rhythms. Animal
studies have revealed daily rhythms in the neuronal activity in the SCN. However, the …

Background The rapid clinical antidepressant effects of the glutamatergic modulator
ketamine may be due to its ability to restore synaptic plasticity and related effects on sleep …

A bstract Bipolar disorder (BD) is a neuropsychiatric illness defined by recurrent episodes of
mania/hypomania, depression and circadian rhythm abnormalities. Lithium is an effective …

This paper reviews some of the compelling evidence of disrupted circadian rhythms in
individuals with mood disorders (major depressive disorder, seasonal affective disorder, and …

Sleep and the circadian clock are intertwined and have persisted throughout history. The
suprachiasmatic nucleus (SCN) orchestrates sleep by controlling circadian (Process C) and …

Within the last few decades, melatonin has increasingly emerged in clinical oncology as a
naturally occurring bioactive molecule with substantial anticancer properties and a …

Background Major depression is a prevalent mood disorder. Chronic stress is presumably
main etiology that leads to the neuron and synapse atrophies in the limbic system. However …