Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases.
This dysfunction manifests as sleep cycle mistiming, alterations in body temperature …

Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons
and regulate synaptic functions. Long thought to be stable structures, PNNs have been …

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a common and
disabling disorder primarily characterized by persistent fatigue and exercise intolerance …

Study objectives This study aimed to examine the effect of sleep-corrected social jetlag
(SJLsc) on mental health, behavioral problems, and daytime sleepiness in adolescents …

Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types
in affected brain regions. Despite this, transcriptomic analyses of the human brain have …

Shift work, commonly defined as work that is performed outside the conventional 9-to-5
working day, is a necessary product of the 24-7 society that requires many industries to be …

Agomelatine is an antidepressant with a unique mechanism of action. Since its marketing in
2009, concerns have been raised regarding its potential to induce liver injury. The authors …

Mammalian physiology and behavior are regulated by an internal time-keeping system,
referred to as circadian rhythm. The circadian timing system has a hierarchical organization …

Circadian rhythms convergently evolved to allow for optimal synchronization of individuals'
physiological and behavioral processes with the Earth's 24-h periodic cycling of …

Circadian rhythms are generated by an endogenously organized timing system that drives
daily rhythms in behavior, physiology and metabolism. In mammals, the suprachiasmatic …