The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
The role of exercise-induced myokines in regulating metabolism
JY Huh - Archives of pharmacal research, 2018 - Springer
Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …
therapeutic regimen of regular exercise and pharmaceutical treatment is often …
Crosstalk between adipokines and myokines in fat browning
A Rodríguez, S Becerril, S Ezquerro… - Acta …, 2017 - Wiley Online Library
Skeletal muscle is the largest organ determining whole‐body insulin sensitivity and
metabolic homoeostasis. Adaptive changes of skeletal muscle in response to physical …
metabolic homoeostasis. Adaptive changes of skeletal muscle in response to physical …
[HTML][HTML] Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
Myostatin (Mstn) is predominantly expressed in skeletal muscles and plays important roles
in regulating muscle growth and development, as well as fat deposition. Mstn-knockout …
in regulating muscle growth and development, as well as fat deposition. Mstn-knockout …
Beyond the body mass index: tracking body composition in the pathogenesis of obesity and the metabolic syndrome
MJ Müller, M Lagerpusch, J Enderle… - Obesity …, 2012 - Wiley Online Library
Body composition is related to various physiological and pathological states.
Characterization of individual body components adds to understand metabolic, endocrine …
Characterization of individual body components adds to understand metabolic, endocrine …
Myostatin and sarcopenia: opportunities and challenges-a mini-review
TA White, NK LeBrasseur - Gerontology, 2014 - karger.com
The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice
E Latres, J Pangilinan, L Miloscio, R Bauerlein, E Na… - Skeletal muscle, 2015 - Springer
Background Loss of skeletal muscle mass and function in humans is associated with
significant morbidity and mortality. The role of myostatin as a key negative regulator of …
significant morbidity and mortality. The role of myostatin as a key negative regulator of …
Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?
R Kob, LC Bollheimer, T Bertsch, C Fellner, M Djukic… - Biogerontology, 2015 - Springer
An age-dependent decline in skeletal muscle mass, strength, and endurance during the
aging process is a physiological development, but several factors may exacerbate this …
aging process is a physiological development, but several factors may exacerbate this …
The failed clinical story of myostatin inhibitors against Duchenne muscular dystrophy: exploring the biology behind the battle
Myostatin inhibition therapy has held much promise for the treatment of muscle wasting
disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy …
disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy …
Current understanding of sarcopenia: possible candidates modulating muscle mass
K Sakuma, W Aoi, A Yamaguchi - Pflügers Archiv-European Journal of …, 2015 - Springer
The world's elderly population is expanding rapidly, and we are now faced with the
significant challenge of maintaining or improving physical activity, independence, and …
significant challenge of maintaining or improving physical activity, independence, and …