[HTML][HTML] Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation
WK Kim, AJ Buckley, DH Lee, A Hiroto… - Nature …, 2024 - nature.com
Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)-signaling
pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually …
pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually …
[HTML][HTML] LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
A Kumaraswamy, Z Duan, D Flores, C Zhang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Abstract Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes
stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies …
stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies …
[HTML][HTML] The Multifaceted Role of Osteopontin in Prostate Pathologies
SV Silver, P Popovics - Biomedicines, 2023 - mdpi.com
The prostate gland, located beneath the bladder and surrounding the proximal urethra in
men, plays a vital role in reproductive physiology and sexual health. Despite its importance …
men, plays a vital role in reproductive physiology and sexual health. Despite its importance …
Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer …
Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions,
most importantly at gene promoters. Many genes have alternative promoters (APs) bound by …
most importantly at gene promoters. Many genes have alternative promoters (APs) bound by …
ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer
C Qian, Q Yang, M Rotinen, R Huang… - Nucleic Acids …, 2024 - academic.oup.com
Abstract Androgen receptor-(AR-) indifference is a mechanism of resistance to hormonal
therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates …
therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates …
[HTML][HTML] ONECUT2 activates diverse resistance drivers of androgen receptor-independent heterogeneity in prostate cancer
C Qian, Q Yang, M Rotinen, R Huang, H Kim, B Gallent… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Abstract Androgen receptor-(AR-) indifference is a mechanism of resistance to hormonal
therapy in prostate cancer (PC). Here we demonstrate that the HOX/CUT transcription factor …
therapy in prostate cancer (PC). Here we demonstrate that the HOX/CUT transcription factor …
[HTML][HTML] Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer
The current study in prostate cancer (PCa) focused on the genomic mechanisms at the cross-
roads of pro-differentiation signals and the emergence of lineage plasticity. We explored an …
roads of pro-differentiation signals and the emergence of lineage plasticity. We explored an …
[HTML][HTML] Unravelling the Role of Iroquois Homeobox 4 and its Interplay with Androgen Receptor in Prostate Cancer
P Janaththani, G Tevz, A Fernando, A Malik… - Research …, 2023 - ncbi.nlm.nih.gov
Genome-wide association studies have linked Iroquois-Homeobox 4 (IRX4) as a robust
expression quantitative-trait locus associated with prostate cancer (PCa) risk. However, the …
expression quantitative-trait locus associated with prostate cancer (PCa) risk. However, the …
[HTML][HTML] Localized high-risk prostate cancer harbors an androgen receptor low subpopulation susceptible to HER2 inhibition
S Wilkinson, AT Ku, RT Lis, IM King, D Low, SY Trostel… - medRxiv, 2024 - ncbi.nlm.nih.gov
Patients diagnosed with localized high-risk prostate cancer have higher rates of recurrence,
and the introduction of neoadjuvant intensive hormonal therapies seeks to treat occult …
and the introduction of neoadjuvant intensive hormonal therapies seeks to treat occult …