Background Persistent negative symptoms (PNS) include both primary and secondary
negative symptoms that persist after adequate treatment, and represent an unmet …

Mapping structural spatial change (ie, gradients) in the striatum is essential for
understanding the function of the basal ganglia in both health and disease. We developed a …

Patients with β-thalassemia (β-TM) may have brain iron overload from long-term blood
transfusions, ineffective erythropoiesis, and increased intestinal iron absorption, leading to …

BACKGROUND AND PURPOSE: Both dual-energy CT and quantitative susceptibility
mapping can evaluate iron depositions in the brain. The purpose of this study was to …

Background and Objectives Noninvasive and accurate biomarkers of neurologic Wilson
disease (NWD), a rare inherited disorder, could reduce diagnostic error or delay. Excessive …

Parkinson's disease (PD) is a progressive neurodegenerative disorder dominated by motor
and non-motor dysfunction. Despite extensive research, the in vivo characterization of PD …

The results of many modern studies show the significance of the role of changes in iron
metabolism and its increased accumulation in the pathogenesis of neurodegenerative and …