Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical
implications for patients and significant economic consequences for society. The prevalence …

The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Background We previously described the contributions of increased total airway mucin
concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of …

Background We evaluated the effect of dual, longacting inhaled bronchodilator treatment on
exacerbations in patients with severe and very severe chronic obstructive pulmonary …

Background: Patients with chronic obstructive pulmonary disease (COPD) often present with
severe acute exacerbations requiring hospital treatment. However, little is known about the …

Treatment of chronic obstructive pulmonary disease (COPD) exacerbations improves
outcomes; however, responses to treatment are variable, and patients with COPD often …

Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of …

The epidemiology of exacerbations of chronic obstructive pulmonary disease (COPD) is
reviewed with particular reference to the definition, frequency, time course, natural history …

Purpose Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity
and mortality in the United States. Exacerbations—acute worsening of COPD symptoms …

Background: A study was undertaken to assess both oxidative stress and inflammation in the
lungs of patients with chronic obstructive pulmonary disease (COPD) during severe and very …