The assessment of percutaneous permeation of molecules is a key step in the evaluation of
dermal or transdermal delivery systems. If the drugs are intended for delivery to humans, the …

Skin drug delivery is an emerging route in drug development, leading to an urgent need to
understand the behaviour of active pharmaceutical ingredients within the skin. Given, As …

Background Prurigo nodularis (PN) is a debilitating, difficult-to-treat, intensely pruritic,
chronic inflammatory skin disease characterized by hyperkeratotic skin nodules. The …

Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic
comorbidities representing a significant burden on patients, their families, and society …

Preclinical research remains hampered by an inadequate representation of human tissue
environments which results in inaccurate predictions of a drug candidate's effects and …

The keratinocyte (KC) is the main functional and structural component of the epidermis, the
most external layer of the skin that is highly specialized in defense against external agents …

Host defence peptides (HDPs), also known as antimicrobial peptides, are naturally occurring
polypeptides (~ 12-50 residues) composed of cationic and hydrophobic amino acids that …

Atopic dermatitis (AD) is a complex inflammatory skin condition that is not fully understood.
Epidermal barrier defects and Th2 immune response dysregulations are thought to play …

Atopic dermatitis (AD) is one of the most prevalent inflammatory skin diseases that is
characterized by eczematous rashes, intense itching, dry skin, and sensitive skin. Although …

Atopic dermatitis (AD) is a chronic inflammatory skin disease of increasing prevalence,
especially in industrialized countries. Roughly 25% of the children and 1%‐3% of adults are …