The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

Islet transplantation is a promising long-term, compliance-free, complication-preventing
treatment for type 1 diabetes. However, islet transplantation is currently limited to a narrow …

Type 1 diabetes (T1D) is an autoimmune disorder in which the body's own immune system
selectively attacks beta cells within pancreatic islets resulting in insufficient insulin …

Macroencapsulation is a powerful approach to increase the efficiency of extrahepatic
pancreatic islet transplant. FTY720, a small molecule that activates signaling through …

Type 1 diabetes mellitus is an autoimmune disorder of the endocrine pancreas that currently
affects millions of people in the United States. Although the disease can be managed with …

Following the tremendous development of hydrogels for cell therapy, there is now a growing
need for surgical techniques to validate in vivo scaffold benefits for islet transplantation …

Islet transplantation is a curative treatment for patients suffering from type 1 diabetes and
has the potential to replace current treatment strategies involving the exogenous …

With the purpose of examining cross-linking agents, we used glutaraldehyde and
ammonium persulfate to synthesize nanohydrogels based on poly (vinyl alcohol), chitosan …

Microencapsulation is being investigated as a means to avoid rejection of transplanted
pancreatic islets. Monitoring bead distribution and stability in vivo is an important step …

Despite their potential for treating type 1 diabetes (T1D), induced pluripotent stem cells
(iPSCs) have not yet been used successfully in the clinic. In this article, advances in iPSC …