Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence

E Christaki, M Marcou, A Tofarides - Journal of molecular evolution, 2020 - Springer
In recent years, we have seen antimicrobial resistance rapidly emerge at a global scale and
spread from one country to the other faster than previously thought. Superbugs and …

Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution

MR Gillings, WH Gaze, A Pruden, K Smalla… - The ISME …, 2015 - academic.oup.com
Around all human activity, there are zones of pollution with pesticides, heavy metals,
pharmaceuticals, personal care products and the microorganisms associated with human …

Occurrence of antibiotics and antibiotic resistance genes in WWTP effluent-receiving water bodies and reclaimed wastewater treatment plants

R Wang, M Ji, H Zhai, Y Guo, Y Liu - Science of the Total Environment, 2021 - Elsevier
There is a growing concern on the fate and the consequent ecological or health risks of
antibiotics and antibiotic resistance genes (ARGs) in natural or artificial water environment …

Integrons: past, present, and future

MR Gillings - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

Resistance integrons: class 1, 2 and 3 integrons

Y Deng, X Bao, L Ji, L Chen, J Liu, J Miao… - Annals of clinical …, 2015 - Springer
As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary
treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for …

Antimicrobial use in aquaculture re‐examined: its relevance to antimicrobial resistance and to animal and human health

FC Cabello, HP Godfrey, A Tomova… - Environmental …, 2013 - Wiley Online Library
The worldwide growth of aquaculture has been accompanied by a rapid increase in
therapeutic and prophylactic usage of antimicrobials including those important in human …

Origins and evolution of antibiotic resistance

J Davies, D Davies - Microbiology and molecular biology reviews, 2010 - Am Soc Microbiol
Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …

Metagenomic insights into chlorination effects on microbial antibiotic resistance in drinking water

P Shi, S Jia, XX Zhang, T Zhang, S Cheng, A Li - Water research, 2013 - Elsevier
This study aimed to investigate the chlorination effects on microbial antibiotic resistance in a
drinking water treatment plant. Biochemical identification, 16S rRNA gene cloning and …

Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens

HW Stokes, MR Gillings - FEMS microbiology reviews, 2011 - academic.oup.com
Antibiotics were one of the great discoveries of the 20th century. However, resistance
appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to …

Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements

E Kristiansson, J Fick, A Janzon, R Grabic… - PloS one, 2011 - journals.plos.org
The high and sometimes inappropriate use of antibiotics has accelerated the development
of antibiotic resistance, creating a major challenge for the sustainable treatment of infections …