Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Despite numerous research efforts, drug delivery through the oral route remains a major
challenge to formulation scientists. The oral delivery of drugs poses a significant challenge …

Coupling hot-melt extrusion (HME) with fused deposition modeling three-dimensional
printing (FDM-3DP) can facilitate the fabrication of tailored, patient-centered, and complex …

As a promising strategy, amorphous solid dispersion has been extensively employed in
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …

The development of amorphous solid dispersions (ASDs) of high-melting-point drug
substances using hot-melt extrusion (HME) continues to be challenging because of the …

Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but
is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot …

Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Resveratrol is a non-flavonoid polyphenol with multiple biological activities; however, the
specific properties of resveratrol present limitations for its clinical application. This study …

Developing amorphous solid dispersions with good flow properties is always challenging for
formulation scientists to convert into tablets. Hence, the present study investigates the impact …

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so
require solubility enhancement. Therefore, ITZ and Kollidon® VA64 (KOL) amorphous solid …