Recent advances in aerosol devices for the delivery of inhaled medications

A Ari, JB Fink - Expert Opinion on Drug Delivery, 2020 - Taylor & Francis
Introduction: Aerosolized medications are commonly prescribed for the treatment of patients
with pulmonary diseases, and there has been an increased interest in the development of …

Inhalation therapy in patients receiving mechanical ventilation: an update

A Ari, JB Fink, R Dhand - … of aerosol medicine and pulmonary drug …, 2012 - liebertpub.com
Incremental gains in understanding the influence of various factors on aerosol delivery in
concert with technological advancements over the past 2 decades have fueled an ever …

How should aerosols be delivered during invasive mechanical ventilation?

R Dhand - Respiratory care, 2017 - rc.rcjournal.com
The delivery of aerosols to mechanically ventilated patients presents unique challenges and
differs from inhaled drug delivery in spontaneously breathing patients in several respects …

Fill volume, humidification and heat effects on aerosol delivery and fugitive emissions during noninvasive ventilation

H Saeed, M Mohsen, JB Fink, P Dailey, AS Eldin… - Journal of Drug Delivery …, 2017 - Elsevier
The aim of this study was to determine the-effect of fill-volume, heat-and-humidification on
aerosol-delivery and fugitive-aerosol-emissions from nebulizers placed proximal to the …

Aerosol therapy in pulmonary critical care

A Ari - Respiratory Care, 2015 - rc.rcjournal.com
Aerosolized medications are routinely used for the treatment of critically ill patients. This
paper reviews aerosol delivery devices with a focus on issues related to their performance in …

[HTML][HTML] Aerosol delivery with two ventilation modes during mechanical ventilation: a randomized study

J Dugernier, G Reychler, X Wittebole, J Roeseler… - Annals of intensive …, 2016 - Springer
Background Volume-controlled ventilation has been suggested to optimize lung deposition
during nebulization although promoting spontaneous ventilation is targeted to avoid …

[HTML][HTML] Aerosol delivery during invasive mechanical ventilation: a systematic review

J Dugernier, S Ehrmann, T Sottiaux, J Roeseler… - Critical Care, 2017 - Springer
Background This systematic review aimed to assess inhaled drug delivery in mechanically
ventilated patients or in animal models. Whole lung and regional deposition and the impact …

In Vitro Comparison of Five Nebulizers During Noninvasive Ventilation: Analysis of Inhaled and Lost Doses

JB Michotte, E Jossen, J Roeseler, G Liistro… - Journal of aerosol …, 2014 - liebertpub.com
Background: Few studies on performance comparison of nebulizer systems coupled with a
single-limb circuit bilevel ventilator are available. Most of these data compared the aerosol …

[HTML][HTML] Impact of gas humidification and nebulizer position under invasive ventilation: preclinical comparative study of regional aerosol deposition

Y Montigaud, Q Georges, L Leclerc, A Clotagatide… - Scientific Reports, 2023 - nature.com
Successful aerosol therapy in mechanically ventilated patients depends on multiple factors.
Among these, position of nebulizer in ventilator circuit and humidification of inhaled gases …

Adjunct Therapies During Mechanical Ventilation: Airway Clearance Techniques, Therapeutic Aerosols, and GasesDiscussion

RH Kallet - Respiratory care, 2013 - rc.rcjournal.com
Mechanically ventilated patients in respiratory failure often require adjunct therapies to
address special needs such as inhaled drug delivery to alleviate airway obstruction, treat …