Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
PC Wong, DJP Pinto, D Zhang - Journal of thrombosis and thrombolysis, 2011 - Springer
Abstract Apixaban (BMS-562247; 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)
phenyl)-4, 5, 6, 7-tetrahydro-1 H-pyrazolo [3, 4-c] pyridine-3-carboxamide), a direct inhibitor …
phenyl)-4, 5, 6, 7-tetrahydro-1 H-pyrazolo [3, 4-c] pyridine-3-carboxamide), a direct inhibitor …
The POCUS consult: how point of care ultrasound helps guide medical decision making
JA Rice, J Brewer, T Speaks, C Choi… - … journal of general …, 2021 - Taylor & Francis
Point of care ultrasound (POCUS) allows for rapid, real-time evaluation of cardiovascular
and respiratory pathology. The advent of portable, handheld devices and increased …
and respiratory pathology. The advent of portable, handheld devices and increased …
COPD and risk of venous thromboembolism and mortality in a general population
T Børvik, SK Brækkan, K Enga… - European …, 2016 - Eur Respiratory Soc
The relationship between chronic obstructive pulmonary disease (COPD) and risk of venous
thromboembolism (VTE) has been scarcely studied in the general population. We aimed to …
thromboembolism (VTE) has been scarcely studied in the general population. We aimed to …
[HTML][HTML] Natural killer cells induce neutrophil extracellular trap formation in venous thrombosis
Essentials• Neutrophil extracellular traps (NETs) are generated during deep vein thrombosis
(DVT).• The role of interferon γ (IFNγ) and natural killer (NK) cells in NET formation was …
(DVT).• The role of interferon γ (IFNγ) and natural killer (NK) cells in NET formation was …
Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism
MF Reiner, D Müller, S Gobbato, O Stalder… - Thrombosis research, 2019 - Elsevier
Introduction Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with
arterial thrombotic events including myocardial infarction and stroke, and mortality. However …
arterial thrombotic events including myocardial infarction and stroke, and mortality. However …
Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides
RA Al-Horani, UR Desai - Journal of Medicinal Chemistry, 2014 - ACS Publications
We recently introduced sulfated pentagalloylglucopyranoside (SPGG) as an allosteric
inhibitor of factor XIa (FXIa)(Al-Horani et al., J. Med Chem. 2013, 56, 867–878). To better …
inhibitor of factor XIa (FXIa)(Al-Horani et al., J. Med Chem. 2013, 56, 867–878). To better …
Timing of chemical thromboprophylaxis and deep vein thrombosis in major colorectal surgery: a randomized clinical trial
KN Zaghiyan, HC Sax, E Miraflor, D Cossman… - Annals of …, 2016 - journals.lww.com
Objective: To identify the optimal timing of perioperative chemical thromboprophylaxis (CTP)
and incidence of occult preoperative deep vein thrombosis (OP-DVT) in patients undergoing …
and incidence of occult preoperative deep vein thrombosis (OP-DVT) in patients undergoing …
Neoadjuvant chemotherapy is associated with increased risk of postoperative DVT after distal pancreatectomy for pancreatic adenocarcinoma: a NSQIP analysis
KJ Robbins, KF Newcomer Jr, EK Barnell… - Annals of Surgical …, 2023 - Springer
Background Venous thromboembolism (VTE) remains a persistent source of postoperative
morbidity despite prevention and mitigation efforts. Cancer, surgery, and chemotherapy are …
morbidity despite prevention and mitigation efforts. Cancer, surgery, and chemotherapy are …
[HTML][HTML] Omega‐3 fatty acids predict recurrent venous thromboembolism or total mortality in elderly patients with acute venous thromboembolism
MF Reiner, S Stivala, A Limacher, NR Bonetti… - Journal of thrombosis …, 2017 - Elsevier
Essentials• The role of omega‐3 fatty acids (n‐3 FAs) in recurrent venous thromboembolism
(VTE) is unknown.• Association of n‐3 FAs with recurrent VTE or total mortality was …
(VTE) is unknown.• Association of n‐3 FAs with recurrent VTE or total mortality was …
Prophylaxis of thromboembolic events in patients with nephrotic syndrome
KJ Pincus, LM Hynicka - Annals of Pharmacotherapy, 2013 - journals.sagepub.com
OBJECTIVE To review published literature regarding use of strategies to prevent thrombotic
events in patients with nephrotic syndrome (NS). DATA SOURCES The MEDLINE/PubMed …
events in patients with nephrotic syndrome (NS). DATA SOURCES The MEDLINE/PubMed …