Mass spectrometry-based metabolomics in microbiome investigations

A Bauermeister, H Mannochio-Russo… - Nature Reviews …, 2022 - nature.com
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …

Metformin: Update on mechanisms of action and repurposing potential

M Foretz, B Guigas, B Viollet - Nature Reviews Endocrinology, 2023 - nature.com
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

The gut microbiota–brain axis in behaviour and brain disorders

LH Morais, HL Schreiber IV… - Nature Reviews …, 2021 - nature.com
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Gut microbiota and its metabolites in depression: from pathogenesis to treatment

L Liu, H Wang, X Chen, Y Zhang, H Zhang, P Xie - EBioMedicine, 2023 - thelancet.com
Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Combinatorial, additive and dose-dependent drug–microbiome associations

SK Forslund, R Chakaroun… - Nature, 2021 - nature.com
During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …

[HTML][HTML] Guts imbalance imbalances the brain: a review of gut microbiota association with neurological and psychiatric disorders

L Mitrea, SA Nemeş, K Szabo, BE Teleky… - Frontiers in …, 2022 - frontiersin.org
In the last ten years, there has been a growing interest regarding the relationship between
gut microbiota, brain, and neurological-associated affections. As multiple preclinical and …

The gut microbiota (microbiome) in cardiovascular disease and its therapeutic regulation

MM Rahman, F Islam, MH -Or-Rashid… - Frontiers in cellular …, 2022 - frontiersin.org
In the last two decades, considerable interest has been shown in understanding the
development of the gut microbiota and its internal and external effects on the intestine, as …