[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people

X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

[PDF][PDF] Aging and the immune system: the impact of immunosenescence on viral infection, immunity and vaccine immunogenicity

CX Chan, YO Yang, GHM Cheng, SK Gera… - Immune …, 2019 - synapse.koreamed.org
Background Prophylactic pinning of the uninvolved side after unilateral slipped capital
femoral epiphysis (SCFE) is controversial. The alpha angle, a measurement of femoral head …

The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

L Sun, W Ma, W Gao, Y Xing, L Chen, Z Xia… - Cell Death & …, 2019 - nature.com
Propofol infusion syndrome (PRIS) is an uncommon life-threatening complication observed
most often in patients receiving high-dose propofol. High-dose propofol treatment with a …

Update on the mechanism and treatment of sevoflurane-induced postoperative cognitive dysfunction

C Wang, W Chen, Y Zhang, S Lin, H He - Frontiers in aging …, 2021 - frontiersin.org
Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of
general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence …

Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson's disease

J Dong, X Wang, C Xu, M Gao, S Wang, J Zhang… - Cell death & …, 2021 - nature.com
Wilson's disease (WD) is an inherited disorder characterized by excessive accumulation of
copper in the body, particularly in the liver and brain. In the central nervous system (CNS) …

Gut microbiota of old mice worsens neurological outcome after brain ischemia via increased valeric acid and IL-17 in the blood

X Zeng, J Li, W Shan, Z Lai, Z Zuo - Microbiome, 2023 - Springer
Background Aging is a significant risk factor for ischemic stroke and worsens its outcome.
However, the mechanisms for this worsened neurological outcome with aging are not clearly …

MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice

L Chen, R Dong, Y Lu, Y Zhou, K Li, Z Zhang… - Brain, behavior, and …, 2019 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common postoperative complication that is
associated with increased morbidity and mortality. However, the neuropathogenesis of this …

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

Y Chang, J Zhu, D Wang, H Li, Y He, K Liu… - Journal of …, 2020 - Springer
Background Brain injury is the leading cause of death and disability in survivors of cardiac
arrest, where neuroinflammation is believed to play a pivotal role, but the underlying …

[HTML][HTML] Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Q Yang, X Wei, B Deng, Z Chang, D Jin, Y Huang… - Neurobiology of …, 2022 - Elsevier
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …