A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Schwann cell-derived exosomal vesicles: a promising therapy for the injured spinal cord

M Ghosh, DD Pearse - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are nanoscale-sized membrane vesicles released by cells into their extracellular
milieu. Within these nanovesicles reside a multitude of bioactive molecules, which …

In Situ Cross-Linkable Hyaluronic–Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury

F Sorouri, P Hosseini, M Sharifzadeh… - … Applied Materials & …, 2023 - ACS Publications
Dysfunctional clinical outcomes following spinal cord injury (SCI) result from glial scar
formation, leading to the inhibition of new axon growth and impaired regeneration …

Composite fibrin/carbon microfiber implants for bridging spinal cord injury: a translational approach in pigs

A Alves-Sampaio, P Del-Cerro… - International Journal of …, 2023 - mdpi.com
Biomaterials may enhance neural repair after spinal cord injury (SCI) and testing their
functionality in large animals is essential to achieve successful clinical translation. This work …

Hydrogel scaffolds in the treatment of spinal cord injury: a review

M Cai, L Chen, T Wang, Y Liang, J Zhao… - Frontiers in …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a disease of the central nervous system often caused by
accidents, and its prognosis is unsatisfactory, with long-term adverse effects on patients' …

Cell Transplantation for Repair of the Spinal Cord and Prospects for Generating Region-Specific Exogenic Neuronal Cells

A Roman, A Huntemer-Silveira… - Cell …, 2024 - journals.sagepub.com
Spinal cord injury (SCI) is associated with currently irreversible consequences in several
functional components of the central nervous system. Despite the severity of injury, there …

Marine Biomaterials: Hyaluronan

RM Abdel-Rahman, AM Abdel-Mohsen - Marine Drugs, 2023 - mdpi.com
The marine-derived hyaluronic acid and other natural biopolymers offer exciting possibilities
in the field of biomaterials, providing sustainable and biocompatible alternatives to synthetic …

Combinatorial strategies for cell transplantation in traumatic spinal cord injury

V Jagrit, J Koffler, JN Dulin - Frontiers in Neuroscience, 2024 - frontiersin.org
Spinal cord injury (SCI) substantially reduces the quality of life of affected individuals.
Recovery of function is therefore a primary concern of the patient population and a primary …

Current multi-scale biomaterials for tissue regeneration following spinal cord injury

Y ang Zhang, Z huan Wu, J feng Wu, T dong Li… - Neurochemistry …, 2024 - Elsevier
Spinal cord injury (SCI) may cause loss of motor and sensory function, autonomic
dysfunction, and thus disrupt the quality of life of patients, leading to severe disability and …

Advancements in neuroregenerative and neuroprotective therapies for traumatic spinal cord injury

G Fischer, L Bättig, MN Stienen, A Curt… - Frontiers in …, 2024 - frontiersin.org
Traumatic spinal cord injuries (SCIs) continue to be a major healthcare concern, with a rising
prevalence worldwide. In response to this growing medical challenge, considerable …