Interferons and multiple sclerosis: Lessons from 25 years of clinical and real-world experience with intramuscular interferon beta-1a (Avonex)

SL Cohan, BA Hendin, AT Reder, K Smoot, R Avila… - CNS drugs, 2021 - Springer
Abstract Recombinant interferon (IFN) β-1b was approved by the US Food and Drug
Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in …

Validation of an algorithm for identifying MS cases in administrative health claims datasets

WJ Culpepper, RA Marrie, A Langer-Gould, MT Wallin… - Neurology, 2019 - AAN Enterprises
Objective To develop a valid algorithm for identifying multiple sclerosis (MS) cases in
administrative health claims (AHC) datasets. Methods We used 4 AHC datasets from the …

Rising incidence of multiple sclerosis in females associated with urbanization

D Kotzamani, T Panou, V Mastorodemos… - Neurology, 2012 - AAN Enterprises
Objective: To design and perform a case-control study of multiple sclerosis (MS) in Crete, an
island of 0.6 million people, that has experienced profound socioeconomic changes in …

The development of cladribine tablets for the treatment of multiple sclerosis: a comprehensive review

K Rammohan, PK Coyle, E Sylvester, A Galazka… - Drugs, 2020 - Springer
Cladribine is a purine nucleoside analog initially developed in the 1970s as a treatment for
various blood cancers. Due to the molecule's ability to preferentially reduce T and B …

Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance

RA Marrie, JD Fisk, BN Yu, S Leung, L Elliott… - BMC neurology, 2013 - Springer
Background While mental comorbidity is considered common in multiple sclerosis (MS), its
impact is poorly defined; methods are needed to support studies of mental comorbidity. We …

Comorbidity increases the risk of hospitalizations in multiple sclerosis

RA Marrie, L Elliott, J Marriott, M Cossoy… - Neurology, 2015 - AAN Enterprises
Objective: We aimed to evaluate the association between comorbidity and rates of
hospitalization in the multiple sclerosis (MS) population as compared to a matched cohort …

Pregnancy outcomes in women with multiple sclerosis

SC MacDonald, TF McElrath… - American journal of …, 2019 - academic.oup.com
Few studies have assessed the risk of adverse pregnancy outcomes in women with multiple
sclerosis (MS). We used 2 large US administrative databases, the Truven Health …

Fatigue, sleep disorders, anaemia and pain in the multiple sclerosis prodrome

FLA Yusuf, JMA Wijnands, E Kingwell… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background: There is increasing evidence of prodromal multiple sclerosis (MS). Objective:
The aim of this study was to determine whether fatigue, sleep disorders, anaemia or pain …

Dramatically changing rates and reasons for hospitalization in multiple sclerosis

RA Marrie, L Elliott, J Marriott, M Cossoy, J Blanchard… - Neurology, 2014 - AAN Enterprises
Objective: We aimed to describe hospitalizations in the multiple sclerosis (MS) population,
and to evaluate temporal trends in hospitalizations in the MS population compared to the …

Association of infectious mononucleosis in childhood and adolescence with risk for a subsequent multiple sclerosis diagnosis among siblings

Y Xu, A Hiyoshi, KA Smith, F Piehl, T Olsson… - JAMA Network …, 2021 - jamanetwork.com
Importance Epstein-Barr virus and its acute manifestation, infectious mononucleosis (IM),
are associated with an increased risk of multiple sclerosis (MS). Whether this association is …