The highly destructive mechanisms by which the immune system faces microbial infections
is under the control of a series of inhibitory receptors. While most of these receptors prevent …

NK cells are capable of an array of functions that range widely from their classic anti-tumor
and anti-viral cytotoxic effector functions, to their critical regulatory roles in controlling …

Adoptive immunotherapy with natural killer cells was pioneered 30 years ago in human
clinical trials with the development of cytokine‐induced killer cells—unfractionated …

Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune
cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia …

Gastrointestinal cancer is one of the leading health problems worldwide, with a high
morbidity and mortality. To date, harnessing both the innate and adaptive immune system …

Natural killer (NK) cells are innate cytotoxic lymphocytes involved in the surveillance and
elimination of cancer. As we have learned more and more about the mechanisms NK cells …

The aging process is associated with chronic low-grade inflammation in both humans and
rodents, commonly called inflammaging. At the same time, there is a gradual decline in the …

Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …