Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

We report herein the first example of a cytochrome P450-catalyzed oxidative carbon–carbon
coupling process for a scalable entry into arylomycin antibiotic cores. Starting from wild-type …

Microorganisms are remarkable chemists, with enzymes as their tools for executing multi-
step syntheses to yield myriad natural products. Microbial synthetic aptitudes are illustrated …

The dimeric diketopiperazine (DKPs) alkaloids are a diverse family of natural products (NPs)
whose unique structural architectures and biological activities have inspired the …

Diketopiperazines are the smallest cyclic peptides comprising two amino acids connected
via two peptide bonds. They can be biosynthesized in nature by two different enzyme …

Covering: 2008 to 2023 This review will describe oxidative phenol coupling as applied in the
total synthesis of natural products. This review covers catalytic and electrochemical methods …

Heterologous expression of a three-gene cluster from Streptomyces aurantiacus coding for a
cyclodipeptide synthase, a prenyltransferase, and a methyltransferase led to the elucidation …

Nature synthesizes many strained natural products that have diverse biological activities.
Uncovering these biosynthetic pathways may lead to biomimetic strategies for organic …

Tailoring enzymes are important modification biocatalysts in natural product biosynthesis.
We report herein six orthologous two‐gene clusters for mycocyclosin and guatyromycine …