Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

MC Chappell - American Journal of Physiology-Heart and …, 2016 - journals.physiology.org
The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

Local renin–angiotensin systems: the unanswered questions

AHJ Danser - The international journal of biochemistry & cell biology, 2003 - Elsevier
The concept of local renin–angiotensin systems has been introduced almost 20 years ago to
explain the beneficial blood pressure-independent effects of ACE inhibitors and AT1 …

Mechanism of high glucose–induced angiotensin II production in rat vascular smooth muscle cells

EN Lavrentyev, AM Estes, KU Malik - Circulation research, 2007 - Am Heart Assoc
Angiotensin II (Ang II), a circulating hormone that can be synthesized locally in the
vasculature, has been implicated in diabetes-associated vascular complications. This study …

Autonomic renal denervation ameliorates experimental glomerulonephritis

R Veelken, EM Vogel, K Hilgers, K Amann… - Journal of the …, 2008 - journals.lww.com
Increasing evidence indicates that inflammation of visceral organs is significantly affected by
the autonomic nervous system. Such neuroimmune interactions have not been studied in …

Release of angiotensin-(1-7) from the rat hindlimb: influence of angiotensin-converting enzyme inhibition

MC Chappell, MN Gomez, NT Pirro, CM Ferrario - Hypertension, 2000 - Am Heart Assoc
The results of recent studies have demonstrated that angiotensin (Ang)-(1-7) contributes to
the antihypertensive actions of either combined ACE/Ang II type 1 receptor blockade or ACE …

Vasoconstriction by in situ formed angiotensin II: role of ACE and chymase

A MaassenVanDenBrink, R de Vries… - Cardiovascular …, 1999 - academic.oup.com
Objective: To assess the importance, for vasoconstriction, of in situ angiotensin (Ang) II
generation, as opposed to Ang II delivery to AT receptors via the organ bath fluid. Methods …

Functional importance of angiotensin-converting enzyme–dependent in situ angiotensin II generation in the human forearm

JJ Saris, MA van Dijk, I Kroon, MADH Schalekamp… - …, 2000 - Am Heart Assoc
To assess the importance for vasoconstriction of in situ angiotensin (Ang) II generation, as
opposed to Ang II delivery via the circulation, we determined forearm vasoconstriction in …

Renin uptake by the endothelium mediates vascular angiotensin formation

KF Hilgers, R Veelken, DN Müller, H Kohler… - …, 2001 - Am Heart Assoc
We investigated the role of the vascular endothelium in the local production of angiotensin.
Angiotensin release from isolated rat hindquarters perfused with an artificial medium was …

Vasoconstriction is determined by interstitial rather than circulating angiotensin II

MP Schuijt, R De Vries, PR Saxena… - British journal of …, 2002 - Wiley Online Library
We investigated why angiotensin (Ang) I and II induce vasoconstriction with similar
potencies, although Ang I‐II conversion is limited. Construction of concentration‐response …

Blood pressure regulation V: in vivo mechanical properties of precapillary vessels as affected by long-term pressure loading and unloading

O Eiken, IB Mekjavic, R Kölegård - European Journal of Applied …, 2014 - Springer
Recent studies are reviewed, concerning the in vivo wall stiffness of arteries and arterioles in
healthy humans, and how these properties adapt to iterative increments or sustained …