Investigating parasites in three dimensions: trends in volume microscopy
To best understand parasite, host, and vector morphologies, host–parasite interactions, and
to develop new drug and vaccine targets, structural data should, ideally, be obtained and …
to develop new drug and vaccine targets, structural data should, ideally, be obtained and …
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities
Protein and phosphoinositide kinases have been successfully exploited as drug targets in
various disease areas, principally in oncology. In malaria, several protein kinases are under …
various disease areas, principally in oncology. In malaria, several protein kinases are under …
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance
Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …
[HTML][HTML] Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis
DA Dos Santos, HFS Souza, AM Silber… - Frontiers in Cellular …, 2023 - frontiersin.org
The apicomplexan parasite Toxoplasma gondii is the causative agent of toxoplasmosis, a
global disease that significantly impacts human health. The clinical manifestations are …
global disease that significantly impacts human health. The clinical manifestations are …
Discovery of Strong 3-Nitro-2-Phenyl-2H-Chromene Analogues as Antitrypanosomal Agents and Inhibitors of Trypanosoma cruzi Glucokinase
SM Carey, DM O'Neill, GB Conner, J Sherman… - International Journal of …, 2024 - mdpi.com
Chagas disease is one of the world's neglected tropical diseases, caused by the human
pathogenic protozoan parasite Trypanosoma cruzi. There is currently a lack of effective and …
pathogenic protozoan parasite Trypanosoma cruzi. There is currently a lack of effective and …
Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium-Specific Insertion
M Dillenberger, AD Werner, AS Velten… - International Journal of …, 2023 - mdpi.com
The protozoan parasite Plasmodium falciparum is the causative pathogen of the most
severe form of malaria, for which novel strategies for treatment are urgently required. The …
severe form of malaria, for which novel strategies for treatment are urgently required. The …
Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity
M Dillenberger, S Rahlfs, K Becker, K Fritz-Wolf - Structure, 2022 - cell.com
The protozoan parasite Plasmodium falciparum causes the most severe form of malaria and
is highly dependent on glycolysis. Glycolytic enzymes were shown to be massively redox …
is highly dependent on glycolysis. Glycolytic enzymes were shown to be massively redox …
Oxidative posttranslational modifications in Plasmodium falciparum and coronaviruses
M Dillenberger - 2022 - jlupub.ub.uni-giessen.de
The protozoan parasite Plasmodium falciparum (P. falciparum) is the causative pathogen of
the most severe form of malaria. For its survival and replication in human erythrocytes, P …
the most severe form of malaria. For its survival and replication in human erythrocytes, P …
[PDF][PDF] Investigating the antimalarial properties of small-molecule compounds and exploring Plasmodium falciparum hexokinase as a potential therapeutic target
A Rogers - 2020 - kb.osu.edu
Malaria, a deadly tropical disease transmitted by infected mosquitos, is caused by
Plasmodium parasites. Plasmodium falciparum is the most pathogenic form, responsible …
Plasmodium parasites. Plasmodium falciparum is the most pathogenic form, responsible …