Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

Introduction Rates of neurocognitive risk range from 35–50% of school-aged children with
isolated single suture craniosynostosis (SSC). It has been hypothesized that early surgical …

This guideline for care of children with craniosynostosis was developed by a national
working group with representatives of 11 matrix societies of specialties and the national …

Craniosynostosis is a defect of the skull caused by early fusion of one or more of the cranial
sutures and affects 3 to 5 individuals per 10,000 live births. Craniosynostosis can be divided …

Objectives Management of raised intracranial pressure in syndromic multi-suture
craniosynostosis by cranial vault expansion can be achieved by a number of techniques. We …

Premature closure of the metopic suture results in a growth restriction of the frontal bones,
which leads to a skull malformation known as trigonocephaly. Over the course of recent …

Crouzon, Apert, Pfeiffer, Muenke, and Saethre-Chotzen syndromes are the five most
common forms of syndromic craniosynostosis. Although each has different genetic …

Background: The neuropsychological morbidity of nonsyndromic craniosynostosis is
incompletely understood. The purpose of this study was to establish the prevalence of …

Premature fusion of one or more of the cranial sutures (craniosynostosis) in humans causes
over 100 skeletal diseases, which occur in 1 of∼ 2,500 live births,,. Among them is Apert …

Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by
premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in …