Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Background Modern pharmacological research found that the chemical components of
Curcuma longa L. are mainly curcumin and turmeric volatile oil. Several recent randomized …

Vascular disease was for a long time considered a disease of the old age, but it is becoming
increasingly clear that a cumulus of factors can cause early vascular aging (EVA) …

Background Vascular activation is characterized by increased proinflammatory, pro
thrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr …

We are witnessing a paradigm shift in drug development and clinical practice to fight the
novel coronavirus disease (COVID-19), and a number of clinical trials have been or are …

Janus kinase (JAK) inhibitors have been developed as disease-modifying antirheumatic
drugs. Despite the positive therapeutic impacts of JAK inhibitors, concerns have been raised …

Janus kinase inhibitors (JAKi) have enormous appeal as immune-modulating therapies
across many chronic inflammatory diseases, but recently this promise has been …

Purpose JAK-inhibitors (JAK-i) might be associated with venous (VTE) and arterial
thromboembolic events (ATE). To evaluate the association between JAK-i and the risk of …

Background & Aims Current therapies for ulcerative colitis (UC) fail to achieve satisfactory
disease control. Selective inhibition of Janus kinase (JAK) type 1 may improve clinical …

Systemic sclerosis and systemic lupus erythematosus represent two distinct autoimmune
diseases belonging to the group of connective tissue disorders. Despite the great progress …