[HTML][HTML] Quantitative non-targeted analysis: bridging the gap between contaminant discovery and risk characterization

JP McCord, LC Groff II, JR Sobus - Environment international, 2022 - Elsevier
Chemical risk assessments follow a long-standing paradigm that integrates hazard, dose–
response, and exposure information to facilitate quantitative risk characterization. Targeted …

New approach methods to evaluate health risks of air pollutants: Critical design considerations for in vitro exposure testing

J Zavala, AN Freedman, JT Szilagyi, I Jaspers… - International journal of …, 2020 - mdpi.com
Air pollution consists of highly variable and complex mixtures recognized as major
contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled …

[PDF][PDF] Transition to sustainable chemistry through digitalization

P Fantke, C Cinquemani, P Yaseneva, J De Mello… - Chem, 2021 - cell.com
Modern chemistry is the backbone of our society, but it is also a major contributor to global
environmental pollution and the ongoing climate crisis. The transition toward a sustainable …

Suspect screening, prioritization, and confirmation of environmental chemicals in maternal-newborn pairs from San Francisco

A Wang, DP Abrahamsson, T Jiang… - … science & technology, 2021 - ACS Publications
Our proof-of-concept study develops a suspect screening workflow to identify and prioritize
potentially ubiquitous chemical exposures in matched maternal/cord blood samples, a …

Towards neuroecosociality: mental health in adversity

N Rose, R Birk, N Manning - Theory, Culture & Society, 2022 - journals.sagepub.com
Social theory has much to gain from taking up the challenges of conceptualizing 'mental
health'. Such an approach to the stunting of human mental life in conditions of adversity …

Critical Assessment of the Chemical Space Covered by LC–HRMS Non-Targeted Analysis

T Hulleman, V Turkina, JW O'Brien… - Environmental …, 2023 - ACS Publications
Non-targeted analysis (NTA) has emerged as a valuable approach for the comprehensive
monitoring of chemicals of emerging concern (CECs) in the exposome. The NTA approach …

Potential for machine learning to address data gaps in human toxicity and ecotoxicity characterization

K von Borries, H Holmquist, M Kosnik… - Environmental …, 2023 - ACS Publications
Machine Learning (ML) is increasingly applied to fill data gaps in assessments to quantify
impacts associated with chemical emissions and chemicals in products. However, the …

The chemical landscape of high-throughput new approach methodologies for exposure

KK Isaacs, P Egeghy, KL Dionisio, KA Phillips… - Journal of exposure …, 2022 - nature.com
The rapid characterization of risk to humans and ecosystems from exogenous chemicals
requires information on both hazard and exposure. The US Environmental Protection …

Chemical and biological assessments of environmental mixtures: A review of current trends, advances, and future perspectives

YS Luo, Z Chen, NH Hsieh, TE Lin - Journal of Hazardous Materials, 2022 - Elsevier
Considering the chemical complexity and toxicity data gaps of environmental mixtures, most
studies evaluate the chemical risk individually. However, humans are usually exposed to a …

[HTML][HTML] Cutting-edge computational chemical exposure research at the US Environmental Protection Agency

TJ Buckley, PP Egeghy, K Isaacs, AM Richard… - Environment …, 2023 - Elsevier
Exposure science is evolving from its traditional “after the fact” and “one chemical at a time”
approach to forecasting chemical exposures rapidly enough to keep pace with the …