Evaluation and management of patients with isolated neutropenia
PE Newburger, DC Dale - Seminars in hematology, 2013 - Elsevier
Neutropenia, defined as an absolute neutrophil count (ANC)< 1.5× 10 9/L, encompasses a
wide range of diagnoses, from normal variants to life-threatening acquired and congenital …
wide range of diagnoses, from normal variants to life-threatening acquired and congenital …
[HTML][HTML] Neutrophils and malaria
EH Aitken, A Alemu, SJ Rogerson - Frontiers in immunology, 2018 - frontiersin.org
Neutrophils are abundant in the circulation and are one of the immune system's first lines of
defense against infection. There has been substantial work carried out investigating the role …
defense against infection. There has been substantial work carried out investigating the role …
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
SL Knackstedt, A Georgiadou, F Apel… - Science …, 2019 - science.org
Neutrophils are essential innate immune cells that extrude chromatin in the form of
neutrophil extracellular traps (NETs) when they die. This form of cell death has potent …
neutrophil extracellular traps (NETs) when they die. This form of cell death has potent …
Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins
Patients with severe malaria treated with artesunate sometimes experience a delayed
hemolytic episode. Artesunate (AS) induces pitting, a splenic process whereby dead …
hemolytic episode. Artesunate (AS) induces pitting, a splenic process whereby dead …
[HTML][HTML] The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children
GM Warimwe, LM Murungi, G Kamuyu… - PloS one, 2013 - journals.plos.org
Background Plasmodium falciparum malaria remains a major cause of illness and death in
sub-Saharan Africa. Young children bear the brunt of the disease and though older children …
sub-Saharan Africa. Young children bear the brunt of the disease and though older children …
[HTML][HTML] Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch …
ME van Wolfswinkel, MCC Langenberg, LJ Wammes… - Malaria journal, 2017 - Springer
Background Both in endemic countries and in imported malaria, changes in total and
differential leukocyte count during Plasmodium falciparum infection have been described …
differential leukocyte count during Plasmodium falciparum infection have been described …
Immunomodulation of artemisinin and its derivatives
W Yao, F Wang, H Wang - Science Bulletin, 2016 - Springer
Abstract In the 1970s, artemisinin (“qinghaosu” in Chinese), a sesquiterpene lactone with an
unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising …
unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising …
[HTML][HTML] Treatment outcomes in a safety observational study of dihydroartemisinin/piperaquine (Eurartesim®) in the treatment of uncomplicated malaria at public …
A Adjei, S Narh-Bana, A Amu, V Kukula, RA Nagai… - Malaria journal, 2016 - Springer
Abstract Background Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO
recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated …
recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated …
[HTML][HTML] Haemoglobin changes and risk of anaemia following treatment for uncomplicated falciparum malaria in sub-Saharan Africa
Background Anaemia is common in malaria. It is important to quantitate the risk of anaemia
and to distinguish factors related to the natural history of disease from potential drug toxicity …
and to distinguish factors related to the natural history of disease from potential drug toxicity …
[HTML][HTML] Monitoring the efficacy and safety of three artemisinin based-combinations therapies in Senegal: results from two years surveillance
K Sylla, A Abiola, RCK Tine, B Faye, D Sow… - BMC infectious …, 2013 - Springer
Background Malaria remains a major public health problem in developing countries. Then in
these countries prompt access to effective antimalarial treatment such as Artemisinin based …
these countries prompt access to effective antimalarial treatment such as Artemisinin based …