Neutropenia, defined as an absolute neutrophil count (ANC)< 1.5× 10 9/L, encompasses a
wide range of diagnoses, from normal variants to life-threatening acquired and congenital …

Neutrophils are abundant in the circulation and are one of the immune system's first lines of
defense against infection. There has been substantial work carried out investigating the role …

Neutrophils are essential innate immune cells that extrude chromatin in the form of
neutrophil extracellular traps (NETs) when they die. This form of cell death has potent …

Patients with severe malaria treated with artesunate sometimes experience a delayed
hemolytic episode. Artesunate (AS) induces pitting, a splenic process whereby dead …

Background Plasmodium falciparum malaria remains a major cause of illness and death in
sub-Saharan Africa. Young children bear the brunt of the disease and though older children …

Background Both in endemic countries and in imported malaria, changes in total and
differential leukocyte count during Plasmodium falciparum infection have been described …

Abstract In the 1970s, artemisinin (“qinghaosu” in Chinese), a sesquiterpene lactone with an
unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising …

Abstract Background Dihydroartemisinin-piperaquine (DHA-PQ) is one of five WHO
recommended artemisinin combination therapy (ACT) for the treatment of uncomplicated …

Background Anaemia is common in malaria. It is important to quantitate the risk of anaemia
and to distinguish factors related to the natural history of disease from potential drug toxicity …

Background Malaria remains a major public health problem in developing countries. Then in
these countries prompt access to effective antimalarial treatment such as Artemisinin based …