Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Cells are equipped with a diverse network of signaling and regulatory proteins that function
as cell cycle regulators and checkpoint proteins to ensure the proper progression of cell …

Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …

DNA double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or
homologous recombination (HR). The C terminal binding protein–interacting protein (CtIP) is …

Polo-like kinase 1 (PLK1) is a key regulator of eukaryotic cell division. During mitosis,
dynamic regulation of PLK1 is crucial for its roles in centrosome maturation, spindle …

Centrosome separation is critical for bipolar spindle formation and the accurate segregation
of chromosomes during mammalian cell mitosis. Kinesin-5 (Eg5) is a microtubule motor …

Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling.
However, how these enzymes can be involved in such a broad spectrum of physiological …

The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation
of kinetochore microtubule (k-MT) attachment stability. Previously, we demonstrated that …

The polo-like kinase 1 (Plk1) is an important mediator of cell cycle regulation and a
recognized anti-cancer molecular target. In addition to its catalytic kinase domain (KD), Plk1 …

The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We
designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting …