Microglia phenotypes in aging and neurodegenerative diseases
MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …
fundamental role in mediating the onset and progression of disease. Microglia, which …
Microglia-Mediated Inflammation and Neural Stem Cell Differentiation in Alzheimer's Disease: Possible Therapeutic Role of KV1.3 Channel Blockade
M Revuelta, J Urrutia, A Villarroel… - Frontiers in Cellular …, 2022 - frontiersin.org
Increase of deposits of amyloid β peptides in the extracellular matrix is landmark during
Alzheimer's Disease (AD) due to the imbalance in the production vs. clearance. This …
Alzheimer's Disease (AD) due to the imbalance in the production vs. clearance. This …
Phenomic microglia diversity as a druggable target in the hippocampus in neurodegenerative diseases
D Lana, G Magni, E Landucci, GL Wenk… - International Journal of …, 2023 - mdpi.com
Phenomics, the complexity of microglia phenotypes and their related functions compels the
continuous study of microglia in disease animal models to find druggable targets for …
continuous study of microglia in disease animal models to find druggable targets for …
The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives
W Zhang, Q Wu, S Hao, S Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is one of the most dangerous types of strokes with a high
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …
The development of drug delivery systems for efficient intracranial hemorrhage therapy
W Yu, B Liu, L Zhou, E Gong, C Che… - Advanced …, 2023 - Wiley Online Library
Intracerebral hemorrhage (ICH) is the most devastating form of stroke, which accounts for 10–
15% of cases and causes high morbidity and mortality. With the continuous exploration of …
15% of cases and causes high morbidity and mortality. With the continuous exploration of …
Role of immune and inflammatory mechanisms in stroke: a review of current advances
H Zhao, Y Li, Y Zhang, WY He, WN Jin - Neuroimmunomodulation, 2022 - karger.com
Stroke accounts for a large proportion of morbidity and mortality burden in China. Moreover,
there is a high prevalence of the leading risk factors for stroke, including hypertension and …
there is a high prevalence of the leading risk factors for stroke, including hypertension and …
PPARγ/RAD21 alleviates peripheral secondary brain injury in rat cerebral hemorrhage model through promoting M2 polarization of microglial cells
Y Jiao, S Ren, L Wang, G Wu - International immunopharmacology, 2023 - Elsevier
Background PPARγ has been reported to participate in intracerebral hemorrhage (ICH)
progression, and recruit RAD21 through binding DNA. Our study aimed to explore the roles …
progression, and recruit RAD21 through binding DNA. Our study aimed to explore the roles …
Exploring the pharmacological mechanism of Naoxueshu oral liquid in the treatment of intracerebral hemorrhage through weighted gene co-expression network …
Y Li, C Tian, Y Wei, H Liu, N An, K Song, Y Sun, Y Gao… - Phytomedicine, 2023 - Elsevier
Background Intracerebral hemorrhage (ICH) is a life-threatening stroke subtype with high
rates of disability and mortality. Naoxueshu oral liquid is a proprietary Chinese medicine that …
rates of disability and mortality. Naoxueshu oral liquid is a proprietary Chinese medicine that …
Lipoxin A4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage
R Futokoro, M Hijioka, M Arata, Y Kitamura - Brain sciences, 2022 - mdpi.com
Intracerebral hemorrhage (ICH) is caused by the rupture of blood vessels in the brain. The
excessive activation of glial cells and the infiltration of numerous inflammatory cells are …
excessive activation of glial cells and the infiltration of numerous inflammatory cells are …
[HTML][HTML] Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy
S Cheng, D Jiang, X Lan, K Liu, C Fan - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Abstract Voltage-gated potassium channel 1.3 (Kv1. 3) has emerged as a pivotal player in
numerous biological processes and pathological conditions, sparking considerable interest …
numerous biological processes and pathological conditions, sparking considerable interest …