Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The development of new CRISPR–Cas genome editing tools continues to drive major
advances in the life sciences. Four classes of CRISPR–Cas-derived genome editing agents …

Genome editing has transformed the life sciences and has exciting prospects for use in
treating genetic diseases. Our laboratory developed base editing to enable precise and …

Although major advances in genomics have initiated an exciting new era of research, a lack
of information regarding cis-regulatory elements has limited the genetic improvement or …

Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad
prospects for human therapeutic model development and livestock breeding. Despite …

CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single
nucleotide mutations in research or therapeutic settings. Efficient base editing requires …

Base editing is a powerful CRISPR-based technology for introducing precise substitutions
into the genome. This technology greatly advances mutagenesis possibilities in vivo …

Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

The incidence and mortality of cancer are the major health issue worldwide. Apart from the
treatments developed to date, the unsatisfactory therapeutic effects of cancers have not …

CRISPR-Cas9 cytidine and adenosine base editors (CBEs and ABEs) can disrupt genes
without introducing double-stranded breaks by inactivating splice sites (BE-splice) or by …