ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Pattern recognition receptors in health and diseases

D Li, M Wu - Signal transduction and targeted therapy, 2021 - nature.com
Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize the
specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged …

Antimicrobial resistance and COVID-19: Intersections and implications

GM Knight, RE Glover, CF McQuaid, ID Olaru… - Elife, 2021 - elifesciences.org
Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR)
was among the top priorities for global public health. Already a complex challenge, AMR …

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

T Mokhtari, F Hassani, N Ghaffari, B Ebrahimi… - Journal of molecular …, 2020 - Springer
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …

C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis

I Huang, R Pranata, MA Lim… - Therapeutic …, 2020 - journals.sagepub.com
Background: Patients critically ill with coronavirus disease-2019 (COVID-19) feature
hyperinflammation, and the associated biomarkers may be beneficial for risk stratification …

[HTML][HTML] Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia

Z Leng, R Zhu, W Hou, Y Feng, Y Yang, Q Han… - Aging and …, 2020 - ncbi.nlm.nih.gov
Abstract A coronavirus (HCoV-19) has caused the novel coronavirus disease (COVID-19)
outbreak in Wuhan, China. Preventing and reversing the cytokine storm may be the key to …

[HTML][HTML] Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies

K Aleksandrova, L Koelman, CE Rodrigues - Redox biology, 2021 - Elsevier
Introduction Oxidative stress and inflammation are known to play a critical role in ageing and
chronic disease development and could therefore represent important targets for developing …

Inflammatory and hematologic markers as predictors of severe outcomes in COVID-19 infection: A systematic review and meta-analysis

TI Hariyanto, KV Japar, F Kwenandar, V Damay… - The American journal of …, 2021 - Elsevier
Background Laboratory testing is commonly performed in patients with COVID-19. Each of
the laboratory parameters has potential value for risk stratification and prediction of COVID …

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

E Kyriazopoulou, T Huet, G Cavalli, A Gori… - The Lancet …, 2021 - thelancet.com
Background Anakinra might improve the prognosis of patients with moderate to severe
COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ …