The S100B protein: A multifaceted pathogenic factor more than a biomarker

F Michetti, ME Clementi, R Di Liddo, F Valeriani… - International Journal of …, 2023 - mdpi.com
S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system.
Its levels in biological fluids are recognized as a reliable biomarker of active neural distress …

Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations

V Bonetto, L Pasetto, I Lisi, M Carbonara… - Frontiers in …, 2022 - frontiersin.org
Background Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
associated with disorders affecting the peripheral and the central nervous system. A high …

[HTML][HTML] Blood biomarkers for traumatic brain injury: A narrative review of current evidence

I Hossain, N Marklund, E Czeiter, P Hutchinson, A Buki - Brain and spine, 2023 - Elsevier
Introduction A blood-based biomarker (BBBM) test could help to better stratify patients with
traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary …

Human in vivo evidence of reduced astrocyte activation and neuroinflammation in patients with treatment‐resistant depression following electroconvulsive therapy

S Xu, X Xie, L Yao, W Wang, H Zhang… - Psychiatry and …, 2023 - Wiley Online Library
Aim The current study aimed to investigate the neuroinflammatory hypothesis of depression
and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing …

Blood‐based biomarkers and traumatic brain injury—A clinical perspective

JP Posti, O Tenovuo - Acta Neurologica Scandinavica, 2022 - Wiley Online Library
Blood‐based biomarkers are promising tools to complement clinical variables and imaging
findings in the diagnosis, monitoring and outcome prediction of traumatic brain injury (TBI) …

Cerebrospinal Fluid and Serum Biomarker Insights in Aneurysmal Subarachnoid Haemorrhage: Navigating the Brain–Heart Interrelationship for Improved Patient …

M Burzyńska, A Uryga, R Załuski, A Goździk, B Adamik… - Biomedicines, 2023 - mdpi.com
The pathophysiological mechanisms underlying severe cardiac dysfunction after
aneurysmal subarachnoid haemorrhage (aSAH) remain poorly understood. In the present …

Inflammation biomarkers IL‑6 and IL‑10 may improve the diagnostic and prognostic accuracy of currently authorized traumatic brain injury tools

C Tsitsipanis, M Miliaraki, E Paflioti… - Experimental and …, 2023 - spandidos-publications.com
Traumatic brain injury (TBI) is currently one of the leading causes of mortality and disability
worldwide. At present, no reliable inflammatory or specific molecular neurobiomarker exists …

Double blast wave primary effect on synaptic, glymphatic, myelin, neuronal and neurovascular markers

D Iacono, EK Murphy, CD Stimpson, F Leonessa… - Brain Sciences, 2023 - mdpi.com
Explosive blasts are associated with neurological consequences as a result of blast waves
impact on the brain. Yet, the neuropathologic and molecular consequences due to blast …

Short-term biological variation of serum glial fibrillary acidic protein

SH Christensen, CVB Hviid, AT Madsen… - Clinical Chemistry and …, 2022 - degruyter.com
Objectives Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker for
intracerebral diseases and is approved for clinical use in traumatic brain injury. GFAP is also …

Clinical complications after a traumatic brain injury and its relation with brain biomarkers

O Yuguero, M Bernal, J Farré, M Martinez-Alonso… - Scientific Reports, 2023 - nature.com
We aimed to find out which are the most frequent complications for patients who suffer a
traumatic brain injury (TBI) and its relation with brain biomarker levels. We conducted a …