Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal
fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the …

Neurofluids is a term introduced to define all fluids in the brain and spine such as blood,
cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily …

Background Brain glymphatic dysfunction may contribute to the development of α-
synucleinopathies. Yet, noninvasive imaging and quantification remain lacking. Purpose To …

Purpose Glymphatic system dysfunction has been reported in animal models of traumatic
brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic system …

The concept of the glymphatic system was proposed more than a decade ago as a
mechanism for interstitial fluid flow and waste removal in the central nervous system. The …

Background It is crucial to maintain the intracranial pressure (ICP) within the physiological
range to ensure proper brain function. The ICP may fluctuate during the light-dark phase …

Importance Sleep disturbances and clinical sleep disorders are associated with all-cause
dementia and neurodegenerative conditions, but it remains unclear how longitudinal …

Recent human and animal model experimental studies revealed novel pathways for fluid
movement, immune cell trafficking and metabolic waste clearance in CNS. These studies …

Purpose A possible pathway behind gadolinium retention in brain is leakage of contrast
agents from blood to cerebrospinal fluid and entry into brain along perivascular (glymphatic) …

Interest in interstitial fluid dynamics has increased since the proposal of the glymphatic
system hypothesis. Abnormal dynamics of the interstitial fluid have been pointed out to be an …