Evolution of natural product scaffolds as potential proteasome inhibitors in developing cancer therapeutics

RH Mir, PA Mir, J Uppal, A Chawla, M Patel, F Bardakci… - Metabolites, 2023 - mdpi.com
Homeostasis between protein synthesis and degradation is a critical biological function
involving a lot of precise and intricate regulatory systems. The ubiquitin-proteasome …

Biosynthetic gene clusters with biotechnological applications in novel Antarctic isolates from Actinomycetota

P Bruna, K Núñez-Montero, MJ Contreras… - Applied Microbiology …, 2024 - Springer
Actinomycetota have been widely described as valuable sources for the acquisition of
secondary metabolites. Most microbial metabolites are produced via metabolic pathways …

Diastereoselective and Enantioselective Synthesis of α-p-Methoxyphenoxy-β-Lactones: Dependence on the Stereoelectronic Properties of the β-Hydroxy-α-p …

JM Witte, J Service, MA Addo, B Semakieh… - The Journal of …, 2022 - ACS Publications
Treatment of β-hydroxy-α-p-methoxyphenoxy carboxylic acids derived from the asymmetric
glycolate aldol addition reaction with p-nitrobenzenesulfonyl chloride yielded divergent …

Taxonogenomics of Culturomica massiliensis gen. nov., sp. nov., and Emergencia timonensis gen. nov., sp. nov. new bacteria isolated from human stool microbiota

A Hamame, R Magdy Wasfy, CI Lo, F Fenollar… - Scientific Reports, 2023 - nature.com
Two new bacterial strains, Marseille-P2698T (CSUR P2698= DSM 103,121) and Marseille-
P2260T (CSUR P2260= DSM 101,844= SN18), were isolated from human stools by the …

Exploring the Potential of Microbial Biomolecules in Advancing Human Health and Environmental Sustainability

N Goel, P Choudhary, L Pattanaik, SK Padhi… - … and Biotechnology: An …, 2024 - Springer
Microbial biomolecules have gained significant attention owing to their remarkable capacity
for promoting advancements in human health and environmental sustainability. This chapter …

Therapeutic Potential of Microbial Metabolites: New Insights and Perspectives

MATS Hashmi, MB Khawar, R Naseem… - … Research and Therapy, 2023 - bmrat.com
Microbes release important metabolites that regulate various physiological activities inside
and outside of organisms. The human gastrointestinal tract is a reservoir of microbes that …

Subtercola endophyticus sp. nov., a cold-adapted bacterium isolated from Abies koreana

L Jiang, Y Peng, J Seo, D Jeon, MG Jo, JH Lee… - Scientific Reports, 2022 - nature.com
A novel Gram-stain-positive, aerobic bacterial strain, designated AK-R2A1-2 T, was isolated
from the surface-sterilized needle leaves of an Abies koreana tree. Strain AK-R2A1-2 T had …

Four-membered ring systems

J Anaya, RM Sánchez - Progress in Heterocyclic Chemistry, 2023 - Elsevier
The chapter covers work published in the calendar year 2021. The synthesis and reactivity
of four-membered heteroatom-containing cycles are reviewed. New developments in the …