Recent advances of multifunctional PLGA nanocarriers in the management of triple-negative breast cancer

YH Dinakar, N Rajana, NU Kumari, V Jain… - AAPS PharmSciTech, 2023 - Springer
Even though chemotherapy stands as a standard option in the therapy of TNBC, problems
associated with it such as anemia, bone marrow suppression, immune suppression, toxic …

Emerging targeted therapeutic strategies for the treatment of triple-negative breast cancer

L Kumari, L Mishra, P Patel, N Sharma… - Journal of Drug …, 2023 - Taylor & Francis
Triple-negative breast cancer (TNBC), a subtype of breast cancer that lacks expression of
oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …

[HTML][HTML] Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness

NS Joe, I Godet, N Milki, NUI Ain, HH Oza… - Breast Cancer …, 2022 - Springer
Breast cancer is the most diagnosed cancer among women. Approximately 15–20% of all
breast cancers are highly invasive triple-negative breast cancer (TNBC) and lack estrogen …

A phthalocyanine-based photosensitizer for effectively combating triple negative breast cancer with enhanced photodynamic anticancer activity and immune response

K Huang, M Yan, H Zhang, J Xue, J Chen - European Journal of Medicinal …, 2022 - Elsevier
Although photodynamic therapy (PDT) has attracted great interest, the photosensitizers in
clinical had weak inhibition on metastasis and invasion of cancers. Additionally the immune …

[HTML][HTML] HER3 functions as an effective therapeutic target in triple negative breast cancer to potentiate the antitumor activity of gefitinib and paclitaxel

H Lyu, F Shen, S Ruan, C Tan, J Zhou, AD Thor… - Cancer Cell …, 2023 - Springer
Background Triple negative breast cancer (TNBC) represents a significant clinical
challenge. Chemotherapy remains the mainstay for a large part of TNBC patients, whereas …

[HTML][HTML] TGFβ governs the pleiotropic activity of NDRG1 in triple-negative breast cancer progression

A López-Tejada, C Griñán-Lisón… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
In triple-negative breast cancer (TNBC), the pleiotropic NDRG1 (N-Myc downstream
regulated gene 1) promotes progression and worse survival, yet contradictory results were …

ERK activation modulates invasiveness and Reactive Oxygen Species (ROS) production in triple negative breast cancer cell lines

A Acosta-Casique, JB Montes-Alvarado, M Barragan… - Cellular …, 2023 - Elsevier
Triple negative breast cancer (TNBC) is the breast cancer subtype with the worst prognosis
and still lacks a targeted therapy. In this study, we found increased ERK phosphorylation in …

Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis

PW Zhao, JX Cui, XM Wang - The Pharmacogenomics Journal, 2024 - nature.com
Objective To explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-
negative breast cancer (TNBC) cells, focusing on its interaction with the …

[HTML][HTML] Signaling pathways and natural compounds in triple-negative breast cancer cell line

C Dewi, A Fristiohady, R Amalia, NK Khairul Ikram… - Molecules, 2022 - mdpi.com
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
having a poor prognosis and rapid metastases. TNBC is characterized by the absence of …

Molecular pathways and therapeutic targets linked to triple-negative breast cancer (TNBC)

M Mustafa, K Abbas, M Alam, W Ahmad… - Molecular and Cellular …, 2024 - Springer
Cancer is a group of diseases characterized by uncontrolled cellular growth, abnormal
morphology, and altered proliferation. Cancerous cells lose their ability to act as anchors …