Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

Overview and new insights into the metabolic syndrome: risk factors and emerging variables in the development of type 2 diabetes and cerebrocardiovascular disease

MR Hayden - Medicina, 2023 - mdpi.com
Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

The alterations and roles of glycosaminoglycans in human diseases

Q Wang, L Chi - Polymers, 2022 - mdpi.com
Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

Sulodexide significantly improves endothelial dysfunction and alleviates chest pain and palpitations in patients with long-COVID-19: insights from TUN-EndCOV study

S Charfeddine, H Ibnhadjamor, J Jdidi… - Frontiers in …, 2022 - frontiersin.org
Objective Non-respiratory long-coronavirus disease 2019 (COVID-19) symptoms are mainly
related to a long-lasting endothelial dysfunction and microcirculation impairment. We …

Polymers inspired by heparin and heparan sulfate for viral targeting

M Hoffmann, NL Snyder, L Hartmann - Macromolecules, 2022 - ACS Publications
Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Vascular endothelial glycocalyx damage and potential targeted therapy in COVID-19

D Zha, M Fu, Y Qian - Cells, 2022 - mdpi.com
COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as
SARS-CoV-2. COVID-19 is characterized by progressive respiratory failure resulting from …

Sympathetic neural overdrive, aortic stiffening, endothelial dysfunction, and impaired exercise capacity in severe COVID-19 survivors: a mid-term study of …

D Faria, RJ Moll-Bernardes, L Testa, CMV Moniz… - …, 2023 - Am Heart Assoc
Background: COVID-19 has become a dramatic health problem during this century. In
addition to high mortality rate, COVID-19 survivors are at increased risk for cardiovascular …

Vascular dysfunctions contribute to the long-term cognitive deficits following COVID-19

Z Shabani, J Liu, H Su - Biology, 2023 - mdpi.com
Simple Summary Although SARS-CoV-2 primarily affects the upper respiratory system and
the lungs, it can also affect vasculature, leading to the impairment of endothelial and multi …

N‐Acetylcysteine and Other Sulfur‐Donors as a Preventative and Adjunct Therapy for COVID‐19

HN du Preez, C Aldous, HG Kruger… - Advances in …, 2022 - Wiley Online Library
The airway epithelial glycocalyx plays an important role in preventing severe acute
respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial …

Targeting arginine in COVID-19-induced immunopathology and vasculopathy

W Durante - Metabolites, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) represents a major public health crisis that has
caused the death of nearly six million people worldwide. Emerging data have identified a …