Plasminogen is an abundant plasma protein that exists in various zymogenic forms.
Plasmin, the proteolytically active form of plasminogen, is known for its essential role in …

Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …

Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory
response in mammals. Due to these roles in inflammation, plasminogen has been …

Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by
activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to …

The extracellular matrix (ECM) is a complex and specialized three-dimensional
macromolecular network, present in nearly all tissues, that also interacts with cell surface …

The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …

The interaction between the serine protease urokinase-type plasminogen activator (uPA)
and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell …

The retinal pigment epithelium (RPE) maintains photoreceptor viability and function,
completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE …

Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots
in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its …

Plasminogen (Plg), the zymogen of plasmin (Plm), is a glycoprotein involved in fibrinolysis
and a wide variety of other physiological processes. Plg dysregulation has been implicated …