Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

[HTML][HTML] Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation

Z Yang, F Xu, AE Teschendorff, Y Zhao… - Frontiers in molecular …, 2022 - frontiersin.org
DNA methylation is one of the most important epigenetic mechanism that governing
regulation of gene expression, aberrant DNA methylation patterns are strongly associated …

From multi-omics approaches to personalized medicine in myocardial infarction

C Zhan, T Tang, E Wu, Y Zhang, M He, R Wu… - Frontiers in …, 2023 - frontiersin.org
Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial
necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe …

LncRNAs and PTEN/PI3K signaling: A symphony of regulation in cancer biology

WH Almalki - Pathology-Research and Practice, 2023 - Elsevier
Abstract The Emergence of Long Non-coding RNAs (lncRNAs) as Key Regulators in Diverse
Biological Processes: A Paradigm Shift in Understanding Gene Expression and its Impact on …

Role of the Notch1 signaling pathway in ischemic heart disease

X Peng, S Wang, H Chen… - … Journal of Molecular …, 2023 - spandidos-publications.com
Ischemic heart disease (IHD) is a prevalent cardiovascular disease characterized by the
formation, progression and rupture of atherosclerotic plaque. The Notch signaling pathway …

Apoptosis and myocardial infarction: role of ncRNAs and exosomal ncRNAs

A Farokhian, A Rajabi, A Sheida, A Abdoli, M Rafiei… - …, 2023 - Future Medicine
ncRNAs, particularly miRNAs, lncRNAs and circRNAs, are a group of RNAs which, although
they do not encode proteins (however, recent evidence shows that certain circRNAs are …

[HTML][HTML] DNA methylation of HOX genes and its clinical implications in cancer

X Hu, Y Wang, X Zhang, C Li, X Zhang, D Yang… - Experimental and …, 2023 - Elsevier
Homeobox (HOX) genes encode highly conserved transcription factors that play vital roles in
embryonic development. DNA methylation is a pivotal regulatory epigenetic signaling mark …

[HTML][HTML] Long non-coding RNA LHX1-DT regulates cardiomyocyte differentiation through H2A. Z-mediated LHX1 transcriptional activation

Q Yu, B Cai, Y Zhang, J Xu, D Liu, X Zhang, Z Han… - Iscience, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) play widespread roles in various processes. However,
there is still limited understanding of the precise mechanisms through which they regulate …

Long term exercise-derived exosomal LncRNA CRNDE mitigates myocardial infarction injury through miR-489-3p/Nrf2 signaling axis

W Chen, Q Ye, Y Dong - Nanomedicine: Nanotechnology, Biology and …, 2024 - Elsevier
Myocardial infarction (MI) is a cardiovascular disease and troubles patients all over the
world. Exosomes produced after long-term exercise training were discovered to mediate …

Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway

Q Tan, W Dong, Q Wang, L Gao - DARU Journal of Pharmaceutical …, 2024 - Springer
Background Myocardial ischemia/reperfusion injury (MIRI) seriously threatens the health of
people. The mitochondrial dysfunction in cardiomyocytes can promote the progression of …